p-Nitrotoluene: Target Organs and Levels of Evidence for TR-498
Toxicology and Carcinogenesis Studies of p-Nitrotoluene (CASRN 99-99-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
p-Nitrotoluene
99-99-0 | 05/03/2001 | Dosed-Feed
R&M: 0, 1250, 2500, OR 5000 PPM; 50/SEX/DOSE | Southern Research Institute |
Levels of Evidence
Male Rats: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Skin:
(SUBCUTANEOUS): FIBROMA 1/50 2/50 7/50 1/50 FIBROMA OR FIBROSARCOMA 1/50 2/50 9/50 1/50
|
| Non-Neoplastic Lesions | - KIDNEY: TUBULAR HYALINE DROPLET; TUBULAR PIGMENTATION
- SPLEEN: HEMATOPOIETIC CELL PROLIFERATION; PIGMENTATION
- LIVER: BASOPHILIC FOCUS; CLEAR CELL FOCUS; EOSINOPHILIC FOCUS
- TESTIS: GERMINAL EPITHELIAL ATROPHY
|
| Other Considerations | - DECREASED INCIDENCES: (MONONUCLEAR CELL LEUKEMIA) 24/50 12/50 5/50 4/50
- DECREASED INCIDENCES: (TESTIS: INTERSTITIAL CELL ADENOMA) 49/50 46/50 45/50 34/50
|
Female Rats: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Clitoral Gland:
ADENOMA OR CARCINOMA 8/50 12/50 20/50 8/49
|
| Non-Neoplastic Lesions | - KIDNEY: TUBULAR HYALINE DROPLET; TUBULAR PIGMENTATION; MINERALIZATION; ONCOCYTIC TUBULAR HYPERPLASIA
- SPLEEN: HEMATOPOIETIC CELL PROLIFERATION; PIGMENTATION
- LIVER: EOSINOPHILIC FOCUS
|
| Other Considerations | - DECREASED INCIDENCES: (MONONUCLEAR CELL LEUKEMIA) 13/50 12/50 3/50 1/50
|
Male Mice: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Lung:
ALVEOLAR/BRONCHIOLAR ADEMONA OR CARCINOMA 8/50 14/50 12/50 19/50
|
| Non-Neoplastic Lesions | - LUNG: ALVEOLAR EPITHELIAL BRONCHIOLIZATION; ALVEOLAR EPITHELIAL HYPERPLASIA
|
Female Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - LUNG: ALVEOLAR EPITHELIAL BRONCHIOLIZATION
|
