Target Organs and Levels of Evidence for TR-498
Toxicology and Carcinogenesis Studies of p-Nitrotoluene (CASRN 99-99-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
p-Nitrotoluene
99-99-0 |
05/03/2001 |
Dosed-Feed
R&M: 0, 1250, 2500, OR 5000 PPM; 50/SEX/DOSE |
Southern Research Institute |
Levels of Evidence
Male Rats: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Skin: (SUBCUTANEOUS): FIBROMA 1/50 2/50 7/50 1/50 FIBROMA OR FIBROSARCOMA 1/50 2/50 9/50 1/50
|
| Non-Neoplastic Lesions |
- KIDNEY: TUBULAR HYALINE DROPLET; TUBULAR PIGMENTATION
- SPLEEN: HEMATOPOIETIC CELL PROLIFERATION; PIGMENTATION
- LIVER: BASOPHILIC FOCUS; CLEAR CELL FOCUS; EOSINOPHILIC FOCUS
- TESTIS: GERMINAL EPITHELIAL ATROPHY
|
| Other Considerations |
- DECREASED INCIDENCES: (MONONUCLEAR CELL LEUKEMIA) 24/50 12/50 5/50 4/50
- DECREASED INCIDENCES: (TESTIS: INTERSTITIAL CELL ADENOMA) 49/50 46/50 45/50 34/50
|
Female Rats: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Clitoral Gland: ADENOMA OR CARCINOMA 8/50 12/50 20/50 8/49
|
| Non-Neoplastic Lesions |
- KIDNEY: TUBULAR HYALINE DROPLET; TUBULAR PIGMENTATION; MINERALIZATION; ONCOCYTIC TUBULAR HYPERPLASIA
- SPLEEN: HEMATOPOIETIC CELL PROLIFERATION; PIGMENTATION
- LIVER: EOSINOPHILIC FOCUS
|
| Other Considerations |
- DECREASED INCIDENCES: (MONONUCLEAR CELL LEUKEMIA) 13/50 12/50 3/50 1/50
|
Male Mice: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Lung: ALVEOLAR/BRONCHIOLAR ADEMONA OR CARCINOMA 8/50 14/50 12/50 19/50
|
| Non-Neoplastic Lesions |
- LUNG: ALVEOLAR EPITHELIAL BRONCHIOLIZATION; ALVEOLAR EPITHELIAL HYPERPLASIA
|
Female Mice: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- LUNG: ALVEOLAR EPITHELIAL BRONCHIOLIZATION
|
