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Target Organs and Levels of Evidence for TR-499

Toxicology and Carcinogenesis Studies of Indium Phosphide (CASRN 22398-80-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Indium phosphide
22398-80-7		 05/18/2000 Inhalation
R&M: 0, 0.03, 0.1, OR 0.3 MG/M3		 Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADEMONA 6/50 13/50 27/50 30/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 10/50 8/50 16/50; COMBINED 7/50 22/50 30/50 35/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 0/50 4/50
  • Adrenal Gland Medulla: BENIGN PHEOCHROMOCYTOMA 10/50 22/50 16/49 23/50 BENIGN OR MALIGNANT PHEOCHROMOCYTOMA 10/50 26/50 18/49 24/50
May Have Been Related
  • Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 16/50 23/50 29/50 25/50
  • Skin: FIBROMA 1/50 4/50 7/50 3/50; FIBROMA OR FIBROSARCOMA 2/50 4/50 8/50 4/50
Non-Neoplastic Lesions
  • LUNG: ATYPICAL HYPERPLASIA; CHRONIC ACTIVE INFLAMMATION; ALVEOLAR EPITHELIUM METAPLASIA; ALVEOLUS PROTEINOSIS; INTERSTITIUM FIBROSIS; ALVEOLAR EPITHELIUM HYPERPLASIA
Female Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADEMONA 0/50 7/50 5/50 19/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 3/50 1/50 11/50; COMBINED 1/50 10/50 6/50 26/50
  • Adrenal Gland Medulla: BENIGN PHEOCHROMOCYTOMA 2/50 6/48 2/50 9/49
May Have Been Related
  • Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 14/50 21/50 14/50 24/50
  • Mammary Gland: CARCINOMA 0/50 8/50 3/50 2/50
Non-Neoplastic Lesions
  • LUNG: ATYPICAL HYPERPLASIA; CHRONIC ACTIVE INFLAMMATION; ALVEOLAR EPITHELIUM METAPLASIA; ALVEOLUS PROTEINOSIS; INTERSTITIUM FIBROSIS; ALVEOLAR EPITHELIUM HYPERPLASIA; SQUAMOUS CYST
  • ADRENAL GLAND: (MEDULLA) HYPERPLASIA
Male Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR CARCINOMA 6/50 15/50 22/50 13/50
  • Liver: ADENOMA 17/50 24/50 23/50 32/50; CARCINOMA 11/50 22/50 23/50 16/50; COMBINED 26/50 40/50 37/50 39/50
May Have Been Related
  • Intestines: CARCINOMA 0/50 1/50 5/50 3/50; ADEMONA OR CARCINOMA 1/50 2/50 6/50 3/50
Non-Neoplastic Lesions
  • LUNG: CHRONIC ACTIVE INFLAMMATION; ALVEOLUS PROTEINOSIS; SEROSA FIBROSIS; PLEURA MESOTHELIUM HYPERPLASIA
  • LIVER: EOSINOPHLILIC FOCUS
  • HEART: (ARTERY) INFLAMMATION
Female Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADEMONA 3/50 6/50 10/50 7/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 6/50 5/50 7/50; COMBINED 4/50 11/50 15/50 14/50
  • Liver: ADENOMA 12/50 14/50 18/50 14/50; CARCINOMA 6/50 17/50 8/50 10/50; COMBINED 18/50 28/50 24/50 23/50
Non-Neoplastic Lesions
  • LUNG: CHRONIC ACTIVE INFLAMMATION; ALVEOLUS PROTEINOSIS; SEROSA FIBROSIS; PLEURA MESOTHELIUM HYPERPLASIA
  • LIVER: EOSINOPHILIC FOCUS
  • HEART: (ARTERY) INFLAMMATION