Naphthalene: Target Organs and Levels of Evidence for TR-500
Toxicology and Carcinogenesis Studies of Naphthalene (CASRN 91-20-3) in F344/N Rats (Inhalation Studies)
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
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Naphthalene 91-20-3 | 05/18/2000 | Inhalation R: 0, 10, 30, OR 60 PPM; 58/SEX/GROUP | Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Clear Evidence
Type | Organ/Tissue (Lesion) |
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Neoplastic Lesions | - Nasal Cavity:
(RESPIRATORY EPITHELIUM) ADENOMA 0/49 6/49 8/48 15/48 (OLFACTORY EPITHELIUM) NEUROBLASTOMA 0/49 0/49 4/48 3/48
|
Non-Neoplastic Lesions | - NASAL CAVITY: (OLFACTORY EPITHELIUM) ATYPICAL HYPERPLASIA; ATROPHY; CHRONIC INFLAMMATION; HYALINE DEGENERATION; (RESPIRATORY EPITHELIUM) HYPERPLASIA; SQUAMOUS METAPLASIA; HYALINE DEGENERATION; GOBLET CELL HYPERPLASIA; (GLANDS) HYPERPLASIA; SQUAMOUS METAPLASIA
|
Female Rats: Clear Evidence
Type | Organ/Tissue (Lesion) |
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Neoplastic Lesions | - Nasal Cavity:
(RESPIRATORY EPITHELIUM) ADENOMA 0/49 0/49 4/49 2/49 (OLFACTORY EPITHELIUM) NEUROBLASTOMA 0/49 2/49 3/49 12/49
|
Non-Neoplastic Lesions | - NASAL CAVITY: (OLFACTORY EPITHELIUM) ATYPICAL HYPERPLASIA; ATROPHY; CHRONIC INFLAMMATION; HYALINE DEGENERATION; (RESPIRATORY EPITHELIUM) HYPERPLASIA; SQUAMOUS METAPLASIA; HYALINE DEGENERATION; GOBLET CELL HYPERPLASIA; (GLANDS) HYPERPLASIA; SQUAMOUS METAPLASIA
|