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Target Organs and Levels of Evidence for TR-501

Toxicology and Carcinogenesis Studies of p,p'-Dichlorodiphenyl Sulfone (CASRN 80-07-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
p,p'-Dichlorodiphenyl sulfone 80-07-9	05/18/2000	Dosed-Feed MR: 0, 10, 30, OR 100 PPM; FR & MICE: 0, 30, 100, OR 300 PPM; 50/SEX/DOSE	Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	LIVER: CENTRILOBULAR HYPERTROPHY

Female Rats: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	LIVER: CENTRILOBULAR HYPERTROPHY; BILE DUCT HYPERPLASIA; CENTRILOBULAR DEGENERATION

Male Mice: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	LIVER: CENTRILOBULAR HYPERTROPHY

Female Mice: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	LIVER: CENTRILOBULAR HYPERTROPHY; EOSINOPHILIC FOCUS