Target Organs and Levels of Evidence for TR-501
Toxicology and Carcinogenesis Studies of p,p'-Dichlorodiphenyl Sulfone (CASRN 80-07-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
p,p'-Dichlorodiphenyl sulfone 80-07-9 |
05/18/2000 |
Dosed-Feed MR: 0, 10, 30, OR 100 PPM; FR & MICE: 0, 30, 100, OR 300 PPM; 50/SEX/DOSE |
Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- LIVER: CENTRILOBULAR HYPERTROPHY
|
Female Rats: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- LIVER: CENTRILOBULAR HYPERTROPHY; BILE DUCT HYPERPLASIA; CENTRILOBULAR DEGENERATION
|
Male Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- LIVER: CENTRILOBULAR HYPERTROPHY
|
Female Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- LIVER: CENTRILOBULAR HYPERTROPHY; EOSINOPHILIC FOCUS
|