Skip to Main Navigation
Skip to Page Content

COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/14850

p,p'-Dichlorodiphenyl sulfone: Target Organs and Levels of Evidence for TR-501

Toxicology and Carcinogenesis Studies of p,p'-Dichlorodiphenyl Sulfone (CASRN 80-07-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN		Peer Review DateRoute/Exposure LevelsStudy Laboratory
p,p'-Dichlorodiphenyl sulfone
80-07-9		05/18/2000Dosed-Feed
MR: 0, 10, 30, OR 100 PPM; FR & MICE: 0, 30, 100, OR 300 PPM; 50/SEX/DOSE		Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LIVER: CENTRILOBULAR HYPERTROPHY
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LIVER: CENTRILOBULAR HYPERTROPHY; BILE DUCT HYPERPLASIA; CENTRILOBULAR DEGENERATION
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LIVER: CENTRILOBULAR HYPERTROPHY
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LIVER: CENTRILOBULAR HYPERTROPHY; EOSINOPHILIC FOCUS