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Target Organs and Levels of Evidence for TR-502

Pituitary Gland: (PARS DISTALIS) ADENOMA 0/45 2/44 0/47 5/41 (REGIMEN A)
Pituitary Gland: (PARS DISTALIS) ADENOMA 0/45 3/36 1/36 1/33 5/41 (REGIMEN B)

Toxicology and Carcinogenesis Studies of Chloral Hydrate (CASRN 302-17-0) in B6C3F1 Mice (Gavage Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Chloral hydrate 302-17-0	05/18/2000	Gavage 0, 25, 50, OR 100 MG/KG	National Center for Toxicological Research

Levels of Evidence

Female Mice: Equivocal Evidence

Type	Organ/Tissue (Lesion)
May Have Been Related	Pituitary Gland: (PARS DISTALIS) ADENOMA 0/45 2/44 0/47 5/41 (REGIMEN A) Pituitary Gland: (PARS DISTALIS) ADENOMA 0/45 3/36 1/36 1/33 5/41 (REGIMEN B)