https://ntp.niehs.nih.gov/go/14860

Target Organs and Levels of Evidence for TR-506

Toxicology and Carcinogenesis Studies of Acrylonitrile (CASRN 107-13-1) in B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Acrylonitrile
107-13-1		 05/03/2001 Gavage
MICE: 0, 2.5, 10, OR 20 MG/KG; 50/SEX/DOSE		 Battelle Columbus Laboratory

Levels of Evidence

Male Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 3/50 4/50 19/50 25/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 8/50 9/50 COMBINED 3/50 4/50 26/50 32/50
  • Harderian Gland: ADENOMA 5/50 16/50 24/50 27/50 ADENOMA OR CARCINOMA 6/50 16/50 27/50 30/50
Non-Neoplastic Lesions
  • FORESTOMACH: EPITHELIAL HYPERPLASIA; HYPERKERATOSIS
  • HARDERIAN GLAND: HYPERPLASIA
Female Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 3/50 6/50 24/50 19/50 SQUAMOUS CELL CARCINOMA 0/50 1/50 1/50 11/50 COMBINED 3/50 7/50 25/50 29/50
  • Harderian Gland: ADENOMA 10/50 10/50 25/50 23/50 ADENOMA OR CARCINOMA 11/50 10/50 26/50 25/50
May Have Been Related
  • Ovary: BENIGN OR MALIGNANT GRANULOSA CELL TUMOR 0/50 0/50 4/50 1/50
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 6/50 6/50 14/50 9/50
Non-Neoplastic Lesions
  • FORESTOMACH: EPITHELIAL HYPERPLASIA
  • OVARY: ATROPHY