Target Organs and Levels of Evidence for TR-506
Toxicology and Carcinogenesis Studies of Acrylonitrile (CASRN 107-13-1) in B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Acrylonitrile
107-13-1 |
05/03/2001 |
Gavage
MICE: 0, 2.5, 10, OR 20 MG/KG; 50/SEX/DOSE |
Battelle Columbus Laboratory |
Levels of Evidence
Male Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Forestomach: SQUAMOUS CELL PAPILLOMA 3/50 4/50 19/50 25/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 8/50 9/50 COMBINED 3/50 4/50 26/50 32/50
- Harderian Gland: ADENOMA 5/50 16/50 24/50 27/50 ADENOMA OR CARCINOMA 6/50 16/50 27/50 30/50
|
| Non-Neoplastic Lesions |
- FORESTOMACH: EPITHELIAL HYPERPLASIA; HYPERKERATOSIS
- HARDERIAN GLAND: HYPERPLASIA
|
Female Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Forestomach: SQUAMOUS CELL PAPILLOMA 3/50 6/50 24/50 19/50 SQUAMOUS CELL CARCINOMA 0/50 1/50 1/50 11/50 COMBINED 3/50 7/50 25/50 29/50
- Harderian Gland: ADENOMA 10/50 10/50 25/50 23/50 ADENOMA OR CARCINOMA 11/50 10/50 26/50 25/50
|
| May Have Been Related |
- Ovary: BENIGN OR MALIGNANT GRANULOSA CELL TUMOR 0/50 0/50 4/50 1/50
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 6/50 6/50 14/50 9/50
|
| Non-Neoplastic Lesions |
- FORESTOMACH: EPITHELIAL HYPERPLASIA
- OVARY: ATROPHY
|
