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Target Organs and Levels of Evidence for TR-507

Toxicology and Carcinogenesis Studies of Vanadium Pentoxide (CASRN 1314-62-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Vanadium pentoxide
1314-62-1		 Inhalation
R&M: 0.0, 1.0, 2.0, 4.0, 8.0, OR 16 MG/M3 (10/S/S)		 IIT Research Institute

Levels of Evidence: None



Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Vanadium pentoxide
1314-62-1		 10/18/2001 Inhalation
R: 0, 0.5, 1, OR 2 MG/M3 M: 0, 1, 2, OR 4 MG/M3; 70/SEX/SPECIES/GROUP		 Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 8/49 5/48 6/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 3/49 1/48 3/50 COMBINED 4/50 10/49 6/48 9/50
Non-Neoplastic Lesions
  • LUNG: ALVEOLAR EPITHELIAL HYPERPLASIA; BRONCHIOLE EPITHELIAL HYPERPLASIA; SQUAMOUS ALVEOLAR EPITHELIAL METAPLASIA; SQUAMOUS BRONCHIOLE METAPLASIA; CHRONIC INFLAMMATION; INTERSTITIAL FIBROSIS; ALVEOLAR HISTIOCYTIC CELL INFILTRATION
  • LARYNX: CHRONIC INFLAMMATION; RESPIRATORY EPITHELIAL EPIGLOTTIS DEGENERATION; RESPIRATORY EPITHELIAL EPIGLOTTIS HYPERPLASIA; RESPIRATORY EPITHELIAL EPIGLOTTIS SQUAMOUS METAPLASIA
  • NASAL CAVITY: GOBLET CELL RESPIRATORY EPITHELIAL HYPERPLASIA
Female Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 0/49 3/49 1/50 0/50 COMBINED ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 0/49 3/49 1/50 1/50
Non-Neoplastic Lesions
  • LUNG: ALVEOLAR EPITHELIAL HYPERPLASIA; BRONCHIOLE EPITHELIAL HYPERPLASIA; SQUAMOUS ALVEOLAR EPITHELIAL METAPLASIA; CHRONIC INFLAMMATION; INTERSTITIAL FIBROSIS; ALVEOLAR HISTIOCYTIC CELL INFILTRATION
  • LARYNX: CHRONIC INFLAMMATION; EPITHELIAL EPIGLOTTIS DEGENERATION; EPITHELIAL EPIGLOTTIS HYPERPLASIA; EPITHELIAL EPIGLOTTIS METAPLASIA
  • NASAL CAVITY: GOBLET CELL RESPIRATORY EPITHELIAL HYPERPLASIA
Male Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 13/50 16/50 26/50 15/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 12/50 29/50 30/50 35/50 COMBINED 22/50 42/50 43/50 43/50
Non-Neoplastic Lesions
  • LUNG: ALVEOLAR EPITHELIAL HYPERPLASIA; BRONCHIOLE EPITHELIAL HYPERPLASIA; CHRONIC INFLAMMATION; ALVEOLAR HISTIOCYTIC CELL INFILTRATION; INTERSTITIAL FIBROSIS
  • LARYNX: EPITHELIAL EPIGLOTTIS SQUAMOUS METAPLASIA
  • NASAL CAVITY: SUPPURATIVE INFLAMMATION; OLFACTORY EPITHELIAL HYALINE DEGENERATION; RESPIRATORY EPITHELIAL HYALINE DEGENERATION; RESPIRATORY EPITHELIAL SQUAMOUS METAPLASIA
Female Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 17/50 23/50 19/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 23/50 18/50 22/50 COMBINED 1/50 32/50 35/50 32/50
Non-Neoplastic Lesions
  • LUNG: ALVEOLAR EPITHELIAL HYPERPLASIA; BRONCHIOLE EPITHELIAL HYPERPLASIA; CHRONIC INFLAMMATION; ALVEOLAR HISTIOCYTIC CELL INFILTRATION; INTERSTITIAL FIBROSIS
  • LARYNX: EPITHELIAL EPIGLOTTIS SQUAMOUS METAPLASIA
  • NASAL CAVITY: SUPPURATIVE INFLAMMATION; OLFACTORY EPITHELIAL ATROPHY; OLFACTORY EPITHELIAL HYALINE DEGENERATION; RESPIRATORY EPITHELIAL HYALINE DEGENERATION; RESPIRATORY EPITHELIAL SQUAMOUS METAPLASIA; RESPIRATORY EPITHELIAL NECROSIS
  • BRONCHIAL LYMPH NODE: HYPERPLASIA