Skip to Main Navigation
Skip to Page Content

COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/6402

Riddelliine: Target Organs and Levels of Evidence for TR-508

Toxicology and Carcinogenesis Studies of Riddelliine (CASRN 23246-96-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN		Peer Review DateRoute/Exposure LevelsStudy Laboratory
Riddelliine
23246-96-0		10/18/2001Gavage
MR: 0 OR 1.0 MG/KG; 50/DOSE FR: 0, 0.01, 0.033, 0.1, 0.33, OR 1.0 MG/KG; 62/DOSE MM: 0, 0.1, 0.3, 1.0, OR 3.0 MG/KG; 50/DOSE FM: 0 OR 3.0 MG/KG; 50/DOSE		Southern Research Institute

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: HEMANGIOSARCOMA 0/50 43/50; ADENOMA 0/50 4/50
  • Hematopoietic System: Hematopoietic System: MONONUCLEAR CELL LEUKEMIA (ALL ORGANS) 2/50 9/50
Non-Neoplastic Lesions
  • LIVER: REGENERATIVE HEPATOCYTE HYPERPLASIA; HEPATOCYTE CYTOMEGALY; FOCAL NECROSIS; EOSINOPHILIC FOCUS; MIXED CELL FOCUS; HEMORRHAGE
  • KIDNEY: TUBULE NECROSIS
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: HEMANGIOSARCOMA 0/50 0/50 0/50 0/50 3/50 38/50; ADENOMA 1/50 0/50 0/50 0/50 1/50 7/50
  • Hematopoietic System: MONONUCLEAR CELL LEUKEMIA (ALL ORGANS) 12/50 8/50 13/50 18/50 18/50 14/50
Non-Neoplastic Lesions
  • LIVER: REGENERATIVE HEPATOCYTE HYPERPLASIA; HEPATOCYTE CYTOMEGALY; FOCAL NECROSIS; EOSINOPHILIC FOCUS; MIXED CELL FOCUS; CLEAR CELL FOCUS; BILE DUCT HYPERPLASIA; HEMORRHAGE
  • KIDNEY: TUBULE NECROSIS; TRANSITIONAL EPITHELIAL HYPERPLASIA
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: HEMANGIOSARCOMA 2/50 1/50 0/50 2/50 31/50
Non-Neoplastic Lesions
  • LIVER: HEPATOCYTE CYTOMEGALY; HEPATOCYTE KARYOMEGALY; CENTRILOBULAR HEPATOCYTE NECROSIS; FOCAL HEMORRHAGE; INCREASED SEVERITY OF FOCAL HEPATOCYTE NECROSIS
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY; GLOMERULOSCLEROSIS; TUBULE KARYOMEGALY; TUBULE DILATATION
Other Considerations
  • LIVER: ADENOMA 16/50 18/50 14/50 5/50 0/50 CARCINOMA 23/50 21/50 19/50 20/50 3/50 COMBINED 36/50 39/50 33/50 23/50 3/50
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 4/50 COMBINED 2/50 13/50
Non-Neoplastic Lesions
  • LIVER: HEPATOCYTE CYTOMEGALY; HEPATOCYTE KARYOMEGALY; BILE DUCT HYPERPLASIA; MIXED CELLULAR INFILTRATION
  • KIDNEY: NEPHROPATHY; INCREASED SEVERITY OF NEPHROPATHY; GLOMERULOSCLEROSIS; TUBULE HYALINE DROPLET ACCUMULATION; TUBULE PIGMENTATION
  • LUNG: ALVEOLAR EPITHELIAL HYPERPLASIA
  • ARTERIES (CHRONIC ARTERIAL INFLAMMATION INCLUDES FOCAL): SMALL INTESTINE (DUODENUM); LARGE INTESTINE (CECUM); KIDNEY; MESENTERY; OVARY; SPLEEN; UTERUS
Other Considerations
  • LIVER: ADENOMA 9/59 0/50 OR CARCINOMA 8/49 0/50 COMBINED 16/49 0/50