Target Organs and Levels of Evidence for TR-508
Toxicology and Carcinogenesis Studies of Riddelliine (CASRN 23246-96-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Riddelliine 23246-96-0 |
10/18/2001 |
Gavage MR: 0 OR 1.0 MG/KG; 50/DOSE FR: 0, 0.01, 0.033, 0.1, 0.33, OR 1.0 MG/KG; 62/DOSE MM: 0, 0.1, 0.3, 1.0, OR 3.0 MG/KG; 50/DOSE FM: 0 OR 3.0 MG/KG; 50/DOSE |
Southern Research Institute |
Levels of Evidence
Male Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: HEMANGIOSARCOMA 0/50 43/50; ADENOMA 0/50 4/50
- Hematopoietic System: Hematopoietic System: MONONUCLEAR CELL LEUKEMIA (ALL ORGANS) 2/50 9/50
|
Non-Neoplastic Lesions |
- LIVER: REGENERATIVE HEPATOCYTE HYPERPLASIA; HEPATOCYTE CYTOMEGALY; FOCAL NECROSIS; EOSINOPHILIC FOCUS; MIXED CELL FOCUS; HEMORRHAGE
- KIDNEY: TUBULE NECROSIS
|
Female Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: HEMANGIOSARCOMA 0/50 0/50 0/50 0/50 3/50 38/50; ADENOMA 1/50 0/50 0/50 0/50 1/50 7/50
- Hematopoietic System: MONONUCLEAR CELL LEUKEMIA (ALL ORGANS) 12/50 8/50 13/50 18/50 18/50 14/50
|
Non-Neoplastic Lesions |
- LIVER: REGENERATIVE HEPATOCYTE HYPERPLASIA; HEPATOCYTE CYTOMEGALY; FOCAL NECROSIS; EOSINOPHILIC FOCUS; MIXED CELL FOCUS; CLEAR CELL FOCUS; BILE DUCT HYPERPLASIA; HEMORRHAGE
- KIDNEY: TUBULE NECROSIS; TRANSITIONAL EPITHELIAL HYPERPLASIA
|
Male Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: HEMANGIOSARCOMA 2/50 1/50 0/50 2/50 31/50
|
Non-Neoplastic Lesions |
- LIVER: HEPATOCYTE CYTOMEGALY; HEPATOCYTE KARYOMEGALY; CENTRILOBULAR HEPATOCYTE NECROSIS; FOCAL HEMORRHAGE; INCREASED SEVERITY OF FOCAL HEPATOCYTE NECROSIS
- KIDNEY: INCREASED SEVERITY OF NEPHROPATHY; GLOMERULOSCLEROSIS; TUBULE KARYOMEGALY; TUBULE DILATATION
|
Other Considerations |
- LIVER: ADENOMA 16/50 18/50 14/50 5/50 0/50 CARCINOMA 23/50 21/50 19/50 20/50 3/50 COMBINED 36/50 39/50 33/50 23/50 3/50
|
Female Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 4/50 COMBINED 2/50 13/50
|
Non-Neoplastic Lesions |
- LIVER: HEPATOCYTE CYTOMEGALY; HEPATOCYTE KARYOMEGALY; BILE DUCT HYPERPLASIA; MIXED CELLULAR INFILTRATION
- KIDNEY: NEPHROPATHY; INCREASED SEVERITY OF NEPHROPATHY; GLOMERULOSCLEROSIS; TUBULE HYALINE DROPLET ACCUMULATION; TUBULE PIGMENTATION
- LUNG: ALVEOLAR EPITHELIAL HYPERPLASIA
- ARTERIES (CHRONIC ARTERIAL INFLAMMATION INCLUDES FOCAL): SMALL INTESTINE (DUODENUM); LARGE INTESTINE (CECUM); KIDNEY; MESENTERY; OVARY; SPLEEN; UTERUS
|
Other Considerations |
- LIVER: ADENOMA 9/59 0/50 OR CARCINOMA 8/49 0/50 COMBINED 16/49 0/50
|