Target Organs and Levels of Evidence for TR-509
Toxicology and Carcinogenesis Studies of 2,4-Hexadienal (89% trans,trans Isomer, CASRN 142-83-6; 11% cis,trans Isomer in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
2,4-Hexadienal
142-83-6 |
10/18/2001 |
Gavage
R: 0, 22.5, 45, OR 90 MG/KG M: 0, 30, 60, OR 120 MG/KG |
Southern Research Institute |
Levels of Evidence
Male Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 3/50 10/50 29/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 2/50 COMBINED 0/50 3/50 11/50 29/50
|
| Non-Neoplastic Lesions |
- FORESTOMACH: EPITHELIAL HYPERPLASIA
|
Female Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 17/50
|
| Non-Neoplastic Lesions |
- FORESTOMACH: EPITHELIAL HYPERPLASIA
|
Male Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Forestomach: SQUAMOUS CELL PAPILLOMA 2/50 4/50 5/50 8/50 OR SQUAMOUS CELL CARCINOMA 0/50 1/50 0/50 2/50 COMBINED 2/50 4/50 5/50 10/50
|
| May Have Been Related |
- Oral Cavity: (TONGUE) SQUAMOUS CELL CARCINOMA 0/50 0/50 0/50 2/50
|
| Non-Neoplastic Lesions |
- FORESTOMACH: SQUAMOUS EPITHELIAL HYPERPLASIA
|
Female Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Forestomach: SQUAMOUS CELL PAPILLOMA 2/50 2/49 11/50 13/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/49 0/50 7/50 COMBINED 2/50 2/49 11/50 18/50
|
| Non-Neoplastic Lesions |
- FORESTOMACH: SQUAMOUS EPITHELIAL HYPERPLASIA
|
