https://ntp.niehs.nih.gov/go/6408

Target Organs and Levels of Evidence for TR-511

Toxicology and Carcinogenesis Studies of Dipropylene Glycol (CASRN 25265-71-8) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Dipropylene glycol
25265-71-8		   Dosed-Water
R&M: 0, 0.5, 1.0, 2.0, 4.0 OR 8.0 % (10/S/S)		 A.D. Little Life Science Laboratories

Levels of Evidence: None

 
Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Dipropylene glycol
25265-71-8		 09/05/2002 Dosed-Water
R: 0, 0.25, 1.0, OR 4.0% M: 0, 1.0, 2.0, OR 4.0%; 50/SEX/DOSE		 Battelle Columbus Laboratory

Levels of Evidence

Male Mice: No Evidence
Female Mice: No Evidence
 
Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Dipropylene glycol
25265-71-8		 09/05/2002 Dosed-Water
R: 0, 2,500, 10,000, or 10,000 ppm; M: 0, 10,000, 20,000 or 40,000 ppm; 50/SEX/DOSE		 Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
  • LIVER: INFLAMMATION, FOCAL, HISTIOCYTIC AND GRANULOMATOUS; BILE DUCT HYPERPLASIA
  • NASAL CAVITY: (OLFACTORY EPITHELIUM) ATROPHY; DEGENERATION; THROMBOSIS
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • LIVER: BILE DUCT HYPERPLASIA
  • NASAL CAVITY: OLFACTORY EPITHELIUM DEGENERATION