Elmiron (sodium pentosanpolysulfate): Target Organs and Levels of Evidence for TR-512
Toxicology and Carcinogenesis Studies of Elmiron® (CASRN 37319-17-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Elmiron (sodium pentosanpolysulfate)
37319-17-8 | 09/05/2002 | Gavage
MR: 0, 14, 42, OR 126 MG/KG FR: 0, 28, 84, OR 252 MG/KG MICE: 0, 56, 168, 504 MG/KG; 50/SEX/DOSE | Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - INTESTINES, RECTUM: MYXOMATOUS CHANGE; CELLULAR INFILTRATION, HISTIOCYTIC
- LUNG: ALVEOLUS, INFLAMMATION, CHRONIC ACTIVE, FOCAL
- LYMPH NODE, MESENTERIC: CELLULAR INFILTRATION, HISTIOCYTIC
- SPLEEN: LYMPHOHISIOCYTIC; HYPERPLASIA
|
Female Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - INTESTINES, RECTUM: MYXOMATOUS CHANGE; CELLULAR INFILTRATION; HISTIOCYTIC
- LUNG: ALVEOLUS, INFLAMMATION, CHRONIC ACTIVE, FOCAL
- LYMPH NODE, MESENTERIC: CELLULAR INFILTRATION, HISTIOCYTIC
|
Male Mice: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
HEMANGIOSARCOMA 2/50 0/50 4/50 9/50
|
| May Have Been Related | - Liver:
ADENOMA OR CARCINOMA 23/50 23/50 26/50 31/50
|
| Non-Neoplastic Lesions | - LIVER: CHRONIC INFLAMMATION
- INTESTINES, RECTUM: CHRONIC ACTIVE INFLAMMATION; NECROSIS; SQUAMOUS METAPLASIA; CELLULAR INFILTRATION, HISTIOCYTIC; MYXOMATOUS CHANGE
- LYMPH NODE, MESENTERIC: CELLULAR INFILTRATION, HISTIOCYTIC
- SPLEEN: CELLULAR INFILTRATION, HISTIOCYTIC
|
Female Mice: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
HEMANGIOSARCOMA 1/50 1/49 1/50 4/49; ADENOMA 7/50 5/49 4/50 15/49; HEPATOCELLULAR ADENOMA OR CARCINOMA 10/50 8/49 9/50 18/49
|
| May Have Been Related | - Hematopoietic System:
MALIGNANT LYMPHOMA (ALL ORGANS) 7/50 8/50 6/50 16/50
|
| Non-Neoplastic Lesions | - LIVER: CLEAR CELL FOCUS
- INTESTINES, RECTUM: CHRONIC ACTIVE INFLAMMATION; NECROSIS; SQUAMOUS METAPLASIA; CELLULAR INFILTRATION, HISTIOCYTIC; MYXOMATOUS CHANGE
- LYMPH NODE, MESENTERIC: CELLULAR INFILTRATION, HISTIOCYTIC
- SPLEEN: CELLULAR INFILTRATION; HISTIOCYTIC
|
