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Target Organs and Levels of Evidence for TR-513

Toxicology and Carcinogenesis Studies of Decalin (CASRN 91-17-8) in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Decalin in Male NBR Rats (Inhalation Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Decalin
91-17-8		 09/05/2002 Inhalation
M&F MICE AND FEMALE RATS: 0, 25, 100, OR 400 PPM MALE RATS: 0, 25, 50, 100, OR 400 PPM (20 MALES); 50/SEX/SPECIES/GROUP		 Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 1/50 2/50 6/49 9/50 5/20 ADENOMA OR CARCINOMA 1/50 3/50 7/49 12/50 6/20
  • Adrenal Gland Medulla: BENIGN OR MALIGNANT PHEOCHROMOCYTOMA 8/49 9/49 13/49 16/49 8/20
Non-Neoplastic Lesions
  • KIDNEY: SEVERITY OF CHRONIC NEPHROPATHY; TUBULE HYPERPLASIA; HYALINE DROPLET ACCUMULATION; PAPILLA MINERALIZATON; PELVIC TRANSITIONAL EPITHELIAL HYPERPLASIA
Female Rats: No Evidence
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • LIVER: EOSINOPHILIC FOCUS; CENTRILOBULAR HYPERTROPHY; NECROSIS; SYNCYTIAL ALTERATION; ERYTHROPHAGOCYTOSIS
Female Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Liver: ADENOMA 7/49 13/50 8/50 17/50 CARCINOMA 4/49 16/50 6/50 5/50 COMBINED 11/49 27/50 14/50 20/50
  • Uterus/Cervix: STROMAL POLYP 0/49 0/50 2/50 3/50 STROMAL POLYP OR STROMAL SARCOMA 0/49 0/50 2/50 4/50