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https://ntp.niehs.nih.gov/go/6416

Propylene glycol mono-t-butyl ether: Target Organs and Levels of Evidence for TR-515

Toxicology and Carcinogenesis Studies of Propylene Glycol Mono-t-Butyl Ether (CASRN 57018-52-7) in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Propylene Glycol Mono-t-Butyl Ether In Male NBR Rats (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DateRoute/Exposure LevelsStudy Laboratory
Propylene glycol mono-t-butyl ether
57018-52-7
05/22/2003Inhalation
R&M: 0, 75, 300, OR 1200 PPM; 50/SEX/SPECIES/GROUP
Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
May Have Been Related
  • Kidney Tubular Cell: ADENOMA (STANDARD EVALUATION) 1/50 1/50 3/49 2/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 1/50 2/50 5/49 4/50 ADENOMA OR CARCINOMA (STANDARD EVALUATION) 1/50 1/50 3/49 3/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 1/50 2/50 5/49 5/50
  • Liver: ADENOMA 3/50 0/50 2/49 6/50
Non-Neoplastic Lesions
  • KIDNEY: HYPERPLASIA; HYALINE DROPLET ACCUMULATION; PAPILLA MINERALIZATION; TRANSITIONAL EPITHELIAL HYPERPLASIA; INCREASED SEVERITY OF NEPHROPATHY
  • LIVER: BASOPHILIC FOCI
  • NASAL CAVITY: EPITHELIAL HYALINE DEGENERATION
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
  • LIVER: CLEAR CELL FOCI
  • NASAL CAVITY: EPITHELIAL HYALINE DEGENERATION
  • EYE: CORNEAL MINERALIZATION
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 18/50 23/49 26/50 36/50 CARCINOMA 9/50 8/49 13/50 11/50 COMBINED 25/50 26/49 33/50 41/50 HEPATOBLASTOMA 0/50 0/49 1/50 5/50
Non-Neoplastic Lesions
  • LIVER: EOSINOPHILIC FOCI; MULTINUCLEATED HEPATOCYTES
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 14/49 8/50 10/50 37/49 CARCINOMA 4/49 8/50 7/50 10/49 COMBINED 18/49 14/50 16/50 41/49 HEPATOBLASTOMA 0/49 0/50 0/50 2/49
Non-Neoplastic Lesions
  • LIVER: EOSINOPHILIC FOCI
  • EYE: CORNEAL MINERALIZATION