Skip to Main Navigation
Skip to Page Content

COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/6416

Propylene glycol mono-t-butyl ether: Target Organs and Levels of Evidence for TR-515

Toxicology and Carcinogenesis Studies of Propylene Glycol Mono-t-Butyl Ether (CASRN 57018-52-7) in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Propylene Glycol Mono-t-Butyl Ether In Male NBR Rats (Inhalation Studies)

Chemical (Study Title)
CASRN		Peer Review DateRoute/Exposure LevelsStudy Laboratory
Propylene glycol mono-t-butyl ether
57018-52-7		05/22/2003Inhalation
R&M: 0, 75, 300, OR 1200 PPM; 50/SEX/SPECIES/GROUP		Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
May Have Been Related
  • Kidney Tubular Cell: ADENOMA (STANDARD EVALUATION) 1/50 1/50 3/49 2/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 1/50 2/50 5/49 4/50 ADENOMA OR CARCINOMA (STANDARD EVALUATION) 1/50 1/50 3/49 3/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 1/50 2/50 5/49 5/50
  • Liver: ADENOMA 3/50 0/50 2/49 6/50
Non-Neoplastic Lesions
  • KIDNEY: HYPERPLASIA; HYALINE DROPLET ACCUMULATION; PAPILLA MINERALIZATION; TRANSITIONAL EPITHELIAL HYPERPLASIA; INCREASED SEVERITY OF NEPHROPATHY
  • LIVER: BASOPHILIC FOCI
  • NASAL CAVITY: EPITHELIAL HYALINE DEGENERATION
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
  • LIVER: CLEAR CELL FOCI
  • NASAL CAVITY: EPITHELIAL HYALINE DEGENERATION
  • EYE: CORNEAL MINERALIZATION
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 18/50 23/49 26/50 36/50 CARCINOMA 9/50 8/49 13/50 11/50 COMBINED 25/50 26/49 33/50 41/50 HEPATOBLASTOMA 0/50 0/49 1/50 5/50
Non-Neoplastic Lesions
  • LIVER: EOSINOPHILIC FOCI; MULTINUCLEATED HEPATOCYTES
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 14/49 8/50 10/50 37/49 CARCINOMA 4/49 8/50 7/50 10/49 COMBINED 18/49 14/50 16/50 41/49 HEPATOBLASTOMA 0/49 0/50 0/50 2/49
Non-Neoplastic Lesions
  • LIVER: EOSINOPHILIC FOCI
  • EYE: CORNEAL MINERALIZATION