Target Organs and Levels of Evidence for TR-515
Toxicology and Carcinogenesis Studies of Propylene Glycol Mono-t-Butyl Ether (CASRN 57018-52-7) in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Propylene Glycol Mono-t-Butyl Ether In Male NBR Rats (Inhalation Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Propylene glycol mono-t-butyl ether
57018-52-7 |
05/22/2003 |
Inhalation
R&M: 0, 75, 300, OR 1200 PPM; 50/SEX/SPECIES/GROUP |
Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| May Have Been Related |
- Kidney Tubular Cell: ADENOMA (STANDARD EVALUATION) 1/50 1/50 3/49 2/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 1/50 2/50 5/49 4/50 ADENOMA OR CARCINOMA (STANDARD EVALUATION) 1/50 1/50 3/49 3/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 1/50 2/50 5/49 5/50
- Liver: ADENOMA 3/50 0/50 2/49 6/50
|
| Non-Neoplastic Lesions |
- KIDNEY: HYPERPLASIA; HYALINE DROPLET ACCUMULATION; PAPILLA MINERALIZATION; TRANSITIONAL EPITHELIAL HYPERPLASIA; INCREASED SEVERITY OF NEPHROPATHY
- LIVER: BASOPHILIC FOCI
- NASAL CAVITY: EPITHELIAL HYALINE DEGENERATION
|
Female Rats: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
- LIVER: CLEAR CELL FOCI
- NASAL CAVITY: EPITHELIAL HYALINE DEGENERATION
- EYE: CORNEAL MINERALIZATION
|
Male Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 18/50 23/49 26/50 36/50 CARCINOMA 9/50 8/49 13/50 11/50 COMBINED 25/50 26/49 33/50 41/50 HEPATOBLASTOMA 0/50 0/49 1/50 5/50
|
| Non-Neoplastic Lesions |
- LIVER: EOSINOPHILIC FOCI; MULTINUCLEATED HEPATOCYTES
|
Female Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 14/49 8/50 10/50 37/49 CARCINOMA 4/49 8/50 7/50 10/49 COMBINED 18/49 14/50 16/50 41/49 HEPATOBLASTOMA 0/49 0/50 0/50 2/49
|
| Non-Neoplastic Lesions |
- LIVER: EOSINOPHILIC FOCI
- EYE: CORNEAL MINERALIZATION
|
