Target Organs and Levels of Evidence for TR-516
Toxicology and Carcinogenesis Studies of 2-Methylimidazole (CASRN 693-98-1) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
2-Methylimidazole 693-98-1 |
05/22/2003 |
Dosed-Feed MR: 0, 300, 1000, OR 3000 PPM; FR: 0, 1000, 2500, OR 5000 PPM; M: 0, 625, 1250, OR 2500 PPM; 60/SEX/SPECIES/GROUP |
Southern Research Institute |
Levels of Evidence
Male Rats: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Thyroid Gland Follicular Cell: ADENOMA OR CARCINOMA 1/48 2/46 1/43 5/50
|
May Have Been Related |
- Liver: ADENOMA OR CARCINOMA 0/50 1/50 3/50 3/50
|
Non-Neoplastic Lesions |
- THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
- LIVER: MIXED CELL FOCUS
|
Female Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Thyroid Gland Follicular Cell: ADENOMA 0/49 0/48 0/42 5/48 CARCINOMA 1/49 1/48 1/42 7/48 COMBINED 1/49 1/48 1/42 11/48
|
May Have Been Related |
- Liver: ADENOMA 1/50 0/49 2/50 4/50
|
Non-Neoplastic Lesions |
- THYROID GLAND: FOLLICULAR CELL HYPERPLASIA; MINERALIZATION
- LIVER: BILE DUCT HYPERPLASIA; GRANULOMATOUS INFLAMMATION; MIXED CELL FOCUS
- SPLEEN: GRANULOMATOUS INFLAMMATION
|
Male Mice: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Thyroid Gland Follicular Cell: ADENOMA 0/50 1/50 0/50 7/50
- Liver: ADENOMA 7/50 14/50 13/50 18/50 CARCINOMA 4/50 8/50 14/50 6/50 COMBINED 10/50 22/50 22/50 22/50
|
Non-Neoplastic Lesions |
- THYROID GLAND: FOLLICULAR CELL HYPERPLASIA; FOLLICULAR CELL HYPERTROPHY
- LIVER: HEPATOCYTE CYTOPLASMIC ALTERATION; HEPATOCYTE KARYOMEGALY; KUPFFER CELL PIGMENTATION
- SPLEEN: HEMATOPOIETIC CELL PROLIFERATION; PIGMENTATION; LYMPHOID FOLLICLE ATROPHY
- BONE MARROW: HYPERPLASIA
- KIDNEY: PIGMENTATION
- EPIDIDYMIS: CHRONIC ACTIVE INFLAMMATION; SPERM GRANULOMA
- TESTES: GERMINAL EPITHELIAL ATROPHY
|
Female Mice: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: ADENOMA 3/50 4/49 6/49 10/50
|
Non-Neoplastic Lesions |
- THYROID GLAND: FOLLICULAR CELL HYPERPLASIA; FOLLICULAR CELL HYPERTROPHY
- SPLEEN: HEMATOPOIETIC CELL PROLIFERATION; PIGMENTATION
|