Water disinfection byproducts (Sodium chlorate): Target Organs and Levels of Evidence for TR-517
Toxicology and Carcinogenesis Studies of Sodium Chlorate (CASRN 7775-09-9) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
---|
Water disinfection byproducts (Sodium chlorate) 7775-09-9 | 12/09/2004 | Dosed-Water R: 0, 125, 1000, OR 2000 MG/L; M: 0, 500, 1000, OR 2000 MG/L; 50/GROUP | Southern Research Institute |
Levels of Evidence
Male Rats: Some Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Thyroid Gland Follicular Cell:
CARCINOMA 0/47 0/44 0/43 4/47 ADENOMA OR CARCINOMA 1/47 0/44 0/43 6/47
|
Non-Neoplastic Lesions | - THYROID GLAND: FOLLICULAR CELL HYPERTROPHY
- SPLEEN: HEMATOPOIETIC CELL PROLIFERATION
- BONE MARROW: HYPERPLASIA
|
Female Rats: Some Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Thyroid Gland Follicular Cell:
ADENOMA OR CARCINOMA 1/47 0/47 1/43 4/46
|
Non-Neoplastic Lesions | - THYROID GLAND: FOLLICULAR CELL HYPERTROPHY; FOLLICULAR CELL MINERALIZATION
|
Male Mice: No Evidence
Female Mice: Equivocal Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Pancreas Islet Cell:
ADENOMA OR CARCINOMA 0/46 2/47 2/49 4/49
|
Non-Neoplastic Lesions | - THYROID GLAND: FOLLICULAR CELL HYPERTROPHY
- BONE MARROW: HYPERPLASIA
|