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Target Organs and Levels of Evidence for TR-517

Toxicology and Carcinogenesis Studies of Sodium Chlorate (CASRN 7775-09-9) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)

Chemical (Study Title)
CASRN
Peer Review Date Route/Exposure Levels Study Laboratory
Water disinfection byproducts (Sodium chlorate)
7775-09-9
12/09/2004 Dosed-Water
R: 0, 125, 1000, OR 2000 MG/L; M: 0, 500, 1000, OR 2000 MG/L; 50/GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: CARCINOMA 0/47 0/44 0/43 4/47 ADENOMA OR CARCINOMA 1/47 0/44 0/43 6/47
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERTROPHY
  • SPLEEN: HEMATOPOIETIC CELL PROLIFERATION
  • BONE MARROW: HYPERPLASIA
Female Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA OR CARCINOMA 1/47 0/47 1/43 4/46
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERTROPHY; FOLLICULAR CELL MINERALIZATION
Male Mice: No Evidence
Female Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Pancreas Islet Cell: ADENOMA OR CARCINOMA 0/46 2/47 2/49 4/49
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERTROPHY
  • BONE MARROW: HYPERPLASIA