Skip to Main Navigation
Skip to Page Content
COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/487

Target Organs and Levels of Evidence for TR-517

Toxicology and Carcinogenesis Studies of Sodium Chlorate (CASRN 7775-09-9) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Water disinfection byproducts (Sodium chlorate)
7775-09-9		 12/09/2004 Dosed-Water
R: 0, 125, 1000, OR 2000 MG/L; M: 0, 500, 1000, OR 2000 MG/L; 50/GROUP		 Southern Research Institute

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: CARCINOMA 0/47 0/44 0/43 4/47 ADENOMA OR CARCINOMA 1/47 0/44 0/43 6/47
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERTROPHY
  • SPLEEN: HEMATOPOIETIC CELL PROLIFERATION
  • BONE MARROW: HYPERPLASIA
Female Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA OR CARCINOMA 1/47 0/47 1/43 4/46
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERTROPHY; FOLLICULAR CELL MINERALIZATION
Male Mice: No Evidence
Female Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Pancreas Islet Cell: ADENOMA OR CARCINOMA 0/46 2/47 2/49 4/49
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERTROPHY
  • BONE MARROW: HYPERPLASIA