https://ntp.niehs.nih.gov/go/9822

Target Organs and Levels of Evidence for TR-518

Toxicology and Carcinogenesis Studies of Triethanolamine (CASRN 102-71-6) in B6C3F1 Mice (Dermal Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Triethanolamine
102-71-6		 05/22/2003 Topical Application
MM: 0, 200, 630, OR 2000 MG/KG; FM: 0, 100, 300, OR 1000 MG/KG		 Battelle Columbus Laboratory

Levels of Evidence

Male Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Liver: HEMANGIOSARCOMA 1/50 0/50 6/50 1/50
Non-Neoplastic Lesions
  • LIVER: EOSINOPHILIC FOCUS
  • SKIN: (EPIDERMAL) HYPERPLASIA; SUPPURATIVE INFLAMMATION; ULCER; (DERMAL) CHRONIC INFLAMMATION
Female Mice: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 9/50 18/50 20/50 33/50 COMBINED 12/50 23/50 24/50 34/50
Non-Neoplastic Lesions
  • LIVER: EOSINOPHILIC FOCUS
  • SKIN: (EPIDERMAL) HYPERPLASIA; SUPPURATIVE INFLAMMATION; ULCER; (DERMAL) CHRONIC INFLAMMATION