https://ntp.niehs.nih.gov/go/9824

Target Organs and Levels of Evidence for TR-519

Toxicology and Carcinogenesis Studies of Stoddard Solvent IIC (CASRN 64742-88-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Stoddard solvent (type lIC)
64742-88-7		 05/22/2003 Inhalation
MR: 0, 138, 550, 1100 MG/M3; FR & M: 0, 550, 1100, OR 2200 MG/M3		 Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Adrenal Gland Medulla: BENIGN PHEOCHROMOCYTOMA 5/50 9/50 13/50 17/50 BENIGN OR MALIGNANT PHEOCHROMOCYTOMA 6/50 9/50 13/50 19/50
May Have Been Related
  • Kidney Tubular Cell: (STANDARD AND EXTENDED EVALUATION COMBINED) ADENOMA 3/50 2/50 3/50 7/50
Non-Neoplastic Lesions
  • KIDNEY: RENAL TUBULE HYPERPLASIA; TRANSITIONAL EPITHELIAL HYPERPLASIA; PAPILLA MINERALIZATION; INCREASED SEVERITY OF NEPHROPATHY
Female Rats: No Evidence
Male Mice: No Evidence
Female Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Liver: ADENOMA 9/50 12/50 15/50 18/50