Target Organs and Levels of Evidence for TR-520
Toxicology and Carcinogenesis Studies of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) in Female Harlan Sprague-Dawley Rats (Gavage Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl) 57465-28-8 |
02/17/2004 |
Gavage FEMALE RATS ONLY: PCB-126 -- 0, 10, 30, 100, 175, 300, 550, OR 1000 NG/KG; 100/DOSE |
Battelle Columbus Laboratory |
Levels of Evidence
Female Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: CHOLANGIOCARCINOMA 0/53 0/55 1/53 0/53 5/53 6/51 22/53 2/50 OR ADENOMA 1/53 2/55 1/53 0/53 2/53 4/51 7/53 0/50 OR HEPATOCHOLANGIOMA 0/53 0/55 0/53 0/53 0/53 0/51 3/53 0/50
- Lung: CYSTIC KERATINIZING EPITHELIOMA 0/53 0/55 0/53 0/53 1/53 11/51 35/51 0/50 OR SQUAMOUS CELL CARCINOMA 0/53 0/55 0/53 0/53 0/53 1/51 2/51 0/50
- Oral Cavity: GINGIVAL SQUAMOUS CELL CARINOMA (ORAL MUCOSA) 0/53 1/55 1/53 1/53 2/53 2/53 7/53 2/50
|
May Have Been Related |
- Adrenal Gland Cortex: ADENOMA OR CARCINOMA 0/52 2/55 1/53 0/53 1/53 1/52 4/53 3/50
- Liver: CHOLANGIOMA 0/53 0/55 0/53 0/53 0/53 1/51 1/53 0/50
|
Non-Neoplastic Lesions |
- LIVER: HEPATOCYTE HYPERTROPHY; MULTINUCLEATED HEPATOCYTE; DIFFUSE FATTY CHANGE; BILE DUCT HYPERPLASIA; BILE DUCT CYST; OVAL CELL HYPERPLASIA; NECROSIS; PIGMENTATION; INFLAMMATION; NODULAR HYPERPLASIA; PORTAL FIBROSIS; CHOLANGIOFIBROSIS; TOXIC HEPATOPATHY
- LUNG: ALVEOLAR EPITHELIUM, METAPLASIA, BRONCHIOLAR; SQUAMOUS METAPLASIA
- ADRENAL CORTEX: ATROPHY; CYTOPLASMIC VACUOLIZATION
- PANCREAS: CHRONIC ACTIVE INFLAMMATION; ACINAR ATROPHY; ACINAR CYTOPLASMIC VACUOLIZATION; ARTERIAL CHRONIC ACTIVE INFLAMMATION
- KIDNEY: NEPHROPATHY; SEVERITY OF NEPHROPATHY
- HEART: CARDIOMYOPATHY
- THYROID GLAND: FOLLICULAR CELL HYPERTROPHY
- THYMUS: ATROPHY; SEVERITY OF ATROPHY
- SPLEEN: LYMPHOID FOLLICULAR ATROPHY
- CLITORAL GLAND: CYSTIC DUCT
- MESENTERY: ARTERIAL CHRONIC ACTIVE INFLAMMATION
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