Target Organs and Levels of Evidence for TR-521
Toxicology and Carcinogenesis Studies of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CASRN 1746-01-6) in Female Harlan Sprague-Dawley Rats (Gavage Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
TEF evaluation (TCDD)
1746-01-6 |
02/17/2004 |
Gavage
FEMALE RATS ONLY: TCDD -- 0, 3, 10, 22, 46, OR 100 NG/KG; 100/DOSE |
Battelle Columbus Laboratory |
Levels of Evidence
Female Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 0/53 0/54 0/53 0/53 1/53 13/53 2/50 OR CHOLANGIOCARCINOMA 0/53 0/54 0/53 1/53 4/53 25/53 2/50
- Lung: CYSTIC KERATINIZING EPITHELIOMA 0/53 0/54 0/53 0/52 0/53 9/52 0/50
- Oral Cavity: GINGIVAL SQAMOUS CELL CARCINOMA (ORAL MUCOSA) 1/53 2/54 1/53 0/53 4/53 10/53 5/50
- Uterus/Cervix: SQUAMOUS CELL CARCINOMA 0/53 0/54 0/53 0/53 5/53 0/53 2/50
|
| May Have Been Related |
- Pancreas Acinar Cell: ADENOMA OR CARCINOMA 0/51 0/54 0/52 0/53 0/52 3/51 1/49
- Liver: HEPATOCHOLANGIOMA 0/53 0/54 0/53 0/53 0/53 2/53 0/50 OR CHOLANGIOMA 0/53 0/54 0/53 0/53 0/53 0/53 1/50
|
| Non-Neoplastic Lesions |
- LIVER: HEPATOCYTE HYPERTROPHY; MULTINUCLEATED HEPATOCYTE; EOSINOPHILIC FOCUS; INFLAMMATION; PIGMENTATION; DIFFUSE FATTY CHANGE; NECROSIS; OVAL CELL HYPERPLASIA; BILE DUCT HYPERPLASIA; BILE DUCT CYST; NODULAR HYPERPLASIA; PORTAL FIBROSIS; TOXIC HEPATOPATHY; CHOLANGIOFIBROSIS
- LUNG: ALVEOLAR EPITHELIUM, METAPLASIA, BRONCHIOLAR
- ORAL MUCOSA: GINGIVAL SQUAMOUS HYPERPLASIA
- PANCREAS: ACINAR CYTOPLASMIC VACUOLIZATION; CHRONIC ACTIVE INFLAMMATION; ACINAR ATROPHY; ARTERIAL CHRONIC ACTIVE INFLAMMATION
- THYMUS: ATROPHY; SEVERITY OF ATROPHY
- ADRENAL CORTEX: ATROPHY; HYPERPLASIA
- HEART: CARDIOMYOPATHY
- CLITORAL GLAND: CYSTIC DUCT
- KIDNEY: NEPHROPATHY; SEVERITY OF NEPHROPATHY
- FORESTOMACH: SQUAMOUS HYPERPLASIA
- MESENTERY: CHRONIC ACTIVE ARTERY INFLAMMATION
- THYROID GLAND: FOLLICULAR CELL HYPERTROPHY
|
