Target Organs and Levels of Evidence for TR-525
Toxicology and Carcinogenesis Studies of 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CASRN 57117-31-4) in Female Harlan Sprague-Dawley Rats (Gavage Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
TEF evaluation (PECDF (Pentachlorodibenzofuran))
57117-31-4 |
02/17/2004 |
Gavage
FEMALE RATS ONLY: PeCDF -- 0, 6, 20, 44, 92, OR 200 NG/KG; 100/DOSE |
Battelle Columbus Laboratory |
Levels of Evidence
Female Rats: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 1/53 0/53 1/53 0/52 2/53 4/53 1/50 OR CHOLANGIOCARCINOMA 0/53 0/53 0/53 1/52 1/53 2/53 0/50
- Oral Cavity: (ORAL MUCOSA) GINGIVAL SQUAMOUS CELL CARCINOMA 1/53 2/53 1/53 0/53 1/53 3/53 3/50
|
| May Have Been Related |
- Lung: CYSTIC KERATINIZING EPITHELIOMA (MULTIPLE) 0/53 0/53 0/53 0/53 0/53 1/52 0/50
- Pancreas Acinar Cell: ADENOMA OR CARCINOMA 0/53 0/53 0/53 0/52 2/52 0/52 2/49
- Uterus/Cervix: CARCINOMA 1/53 1/53 0/53 1/53 5/53 2/53 1/50
|
| Non-Neoplastic Lesions |
- LIVER: HEPATOCYTE HYPERTROPHY; MULTINUCLEATED HEPATOCYTE; OVAL CELL HYPERPLASIA; DIFFUSE FATTY CHANGE; PIGMENTATION; NODULAR HYPERPLASIA; EOSINOPHILIC FOCUS; NECROSIS; BILE DUCT HYPERPLASIA; BILE DUCT FIBROSIS; TOXIC HEPATOPATHY; CHOLANGIOFIBROSIS
- ORAL MUCOSA: GINGIVAL SQUAMOUS HYPERPLASIA
- UTERUS: ENDOMETRIAL CYSTIC HYPERPLASIA; CHRONIC ACTIVE INFLAMMATION; SQUAMOUS METAPLASIA
- LUNG: ALVEOLAR EPITHELIUM, METAPLASIA, BRONCHIOLAR; SQUAMOUS METAPLASIA
- PANCREAS: ACINAR CYTOPLASMIC VACUOLIZATION; ARTERIAL CHRONIC ACTIVE INFLAMMATION
- THYROID GLAND: FOLLICULAR CELL HYPERTROPHY
- THYMUS: ATROPHY; SEVERITY OF ATROPHY
- ADRENAL CORTEX: CYSTIC DEGENERATION
- KIDNEY: NEPHROPATHY; SEVERITY OF NEPHROPATHY
- HEART: CARDIOMYOPATHY
- FORESTOMACH: SQUAMOUS HYPERPLASIA
|
