Toxic equivalency factor evaluation (PECDF (Pentachlorodibenzofuran)): Target Organs and Levels of Evidence for TR-525
Toxicology and Carcinogenesis Studies of 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CASRN 57117-31-4) in Female Harlan Sprague-Dawley Rats (Gavage Studies)
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
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TEF evaluation (PECDF (Pentachlorodibenzofuran)) 57117-31-4 | 02/17/2004 | Gavage FEMALE RATS ONLY: PeCDF -- 0, 6, 20, 44, 92, OR 200 NG/KG; 100/DOSE | Battelle Columbus Laboratory |
Levels of Evidence
Female Rats: Some Evidence
Type | Organ/Tissue (Lesion) |
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Neoplastic Lesions | - Liver:
ADENOMA 1/53 0/53 1/53 0/52 2/53 4/53 1/50 OR CHOLANGIOCARCINOMA 0/53 0/53 0/53 1/52 1/53 2/53 0/50
- Oral Cavity:
(ORAL MUCOSA) GINGIVAL SQUAMOUS CELL CARCINOMA 1/53 2/53 1/53 0/53 1/53 3/53 3/50
|
May Have Been Related | - Lung:
CYSTIC KERATINIZING EPITHELIOMA (MULTIPLE) 0/53 0/53 0/53 0/53 0/53 1/52 0/50
- Pancreas Acinar Cell:
ADENOMA OR CARCINOMA 0/53 0/53 0/53 0/52 2/52 0/52 2/49
- Uterus/Cervix:
CARCINOMA 1/53 1/53 0/53 1/53 5/53 2/53 1/50
|
Non-Neoplastic Lesions | - LIVER: HEPATOCYTE HYPERTROPHY; MULTINUCLEATED HEPATOCYTE; OVAL CELL HYPERPLASIA; DIFFUSE FATTY CHANGE; PIGMENTATION; NODULAR HYPERPLASIA; EOSINOPHILIC FOCUS; NECROSIS; BILE DUCT HYPERPLASIA; BILE DUCT FIBROSIS; TOXIC HEPATOPATHY; CHOLANGIOFIBROSIS
- ORAL MUCOSA: GINGIVAL SQUAMOUS HYPERPLASIA
- UTERUS: ENDOMETRIAL CYSTIC HYPERPLASIA; CHRONIC ACTIVE INFLAMMATION; SQUAMOUS METAPLASIA
- LUNG: ALVEOLAR EPITHELIUM, METAPLASIA, BRONCHIOLAR; SQUAMOUS METAPLASIA
- PANCREAS: ACINAR CYTOPLASMIC VACUOLIZATION; ARTERIAL CHRONIC ACTIVE INFLAMMATION
- THYROID GLAND: FOLLICULAR CELL HYPERTROPHY
- THYMUS: ATROPHY; SEVERITY OF ATROPHY
- ADRENAL CORTEX: CYSTIC DEGENERATION
- KIDNEY: NEPHROPATHY; SEVERITY OF NEPHROPATHY
- HEART: CARDIOMYOPATHY
- FORESTOMACH: SQUAMOUS HYPERPLASIA
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