Skip to Main Navigation
Skip to Page Content

COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/9830

Toxic equivalency factor evaluation (PECDF (Pentachlorodibenzofuran)): Target Organs and Levels of Evidence for TR-525

Toxicology and Carcinogenesis Studies of 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CASRN 57117-31-4) in Female Harlan Sprague-Dawley Rats (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DateRoute/Exposure LevelsStudy Laboratory
TEF evaluation (PECDF (Pentachlorodibenzofuran))
57117-31-4
02/17/2004Gavage
FEMALE RATS ONLY: PeCDF -- 0, 6, 20, 44, 92, OR 200 NG/KG; 100/DOSE
Battelle Columbus Laboratory

Levels of Evidence

Female Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 1/53 0/53 1/53 0/52 2/53 4/53 1/50 OR CHOLANGIOCARCINOMA 0/53 0/53 0/53 1/52 1/53 2/53 0/50
  • Oral Cavity: (ORAL MUCOSA) GINGIVAL SQUAMOUS CELL CARCINOMA 1/53 2/53 1/53 0/53 1/53 3/53 3/50
May Have Been Related
  • Lung: CYSTIC KERATINIZING EPITHELIOMA (MULTIPLE) 0/53 0/53 0/53 0/53 0/53 1/52 0/50
  • Pancreas Acinar Cell: ADENOMA OR CARCINOMA 0/53 0/53 0/53 0/52 2/52 0/52 2/49
  • Uterus/Cervix: CARCINOMA 1/53 1/53 0/53 1/53 5/53 2/53 1/50
Non-Neoplastic Lesions
  • LIVER: HEPATOCYTE HYPERTROPHY; MULTINUCLEATED HEPATOCYTE; OVAL CELL HYPERPLASIA; DIFFUSE FATTY CHANGE; PIGMENTATION; NODULAR HYPERPLASIA; EOSINOPHILIC FOCUS; NECROSIS; BILE DUCT HYPERPLASIA; BILE DUCT FIBROSIS; TOXIC HEPATOPATHY; CHOLANGIOFIBROSIS
  • ORAL MUCOSA: GINGIVAL SQUAMOUS HYPERPLASIA
  • UTERUS: ENDOMETRIAL CYSTIC HYPERPLASIA; CHRONIC ACTIVE INFLAMMATION; SQUAMOUS METAPLASIA
  • LUNG: ALVEOLAR EPITHELIUM, METAPLASIA, BRONCHIOLAR; SQUAMOUS METAPLASIA
  • PANCREAS: ACINAR CYTOPLASMIC VACUOLIZATION; ARTERIAL CHRONIC ACTIVE INFLAMMATION
  • THYROID GLAND: FOLLICULAR CELL HYPERTROPHY
  • THYMUS: ATROPHY; SEVERITY OF ATROPHY
  • ADRENAL CORTEX: CYSTIC DEGENERATION
  • KIDNEY: NEPHROPATHY; SEVERITY OF NEPHROPATHY
  • HEART: CARDIOMYOPATHY
  • FORESTOMACH: SQUAMOUS HYPERPLASIA