https://ntp.niehs.nih.gov/go/9830

Target Organs and Levels of Evidence for TR-525

Toxicology and Carcinogenesis Studies of 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CASRN 57117-31-4) in Female Harlan Sprague-Dawley Rats (Gavage Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
TEF evaluation (PECDF (Pentachlorodibenzofuran))
57117-31-4		 02/17/2004 Gavage
FEMALE RATS ONLY: PeCDF -- 0, 6, 20, 44, 92, OR 200 NG/KG; 100/DOSE		 Battelle Columbus Laboratory

Levels of Evidence

Female Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 1/53 0/53 1/53 0/52 2/53 4/53 1/50 OR CHOLANGIOCARCINOMA 0/53 0/53 0/53 1/52 1/53 2/53 0/50
  • Oral Cavity: (ORAL MUCOSA) GINGIVAL SQUAMOUS CELL CARCINOMA 1/53 2/53 1/53 0/53 1/53 3/53 3/50
May Have Been Related
  • Lung: CYSTIC KERATINIZING EPITHELIOMA (MULTIPLE) 0/53 0/53 0/53 0/53 0/53 1/52 0/50
  • Pancreas Acinar Cell: ADENOMA OR CARCINOMA 0/53 0/53 0/53 0/52 2/52 0/52 2/49
  • Uterus/Cervix: CARCINOMA 1/53 1/53 0/53 1/53 5/53 2/53 1/50
Non-Neoplastic Lesions
  • LIVER: HEPATOCYTE HYPERTROPHY; MULTINUCLEATED HEPATOCYTE; OVAL CELL HYPERPLASIA; DIFFUSE FATTY CHANGE; PIGMENTATION; NODULAR HYPERPLASIA; EOSINOPHILIC FOCUS; NECROSIS; BILE DUCT HYPERPLASIA; BILE DUCT FIBROSIS; TOXIC HEPATOPATHY; CHOLANGIOFIBROSIS
  • ORAL MUCOSA: GINGIVAL SQUAMOUS HYPERPLASIA
  • UTERUS: ENDOMETRIAL CYSTIC HYPERPLASIA; CHRONIC ACTIVE INFLAMMATION; SQUAMOUS METAPLASIA
  • LUNG: ALVEOLAR EPITHELIUM, METAPLASIA, BRONCHIOLAR; SQUAMOUS METAPLASIA
  • PANCREAS: ACINAR CYTOPLASMIC VACUOLIZATION; ARTERIAL CHRONIC ACTIVE INFLAMMATION
  • THYROID GLAND: FOLLICULAR CELL HYPERTROPHY
  • THYMUS: ATROPHY; SEVERITY OF ATROPHY
  • ADRENAL CORTEX: CYSTIC DEGENERATION
  • KIDNEY: NEPHROPATHY; SEVERITY OF NEPHROPATHY
  • HEART: CARDIOMYOPATHY
  • FORESTOMACH: SQUAMOUS HYPERPLASIA