Toxic equivalency factor evaluation (Dioxin mixture): Target Organs and Levels of Evidence for TR-526
Toxicology and Carcinogenesis Studies of a Mixture of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) (CASRN 1746-01-6), 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CASRN 57117-31-4), and 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) in Female Harlan Sprague-Dawley Rats (Gavage Studies)
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
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TEF evaluation (Dioxin mixture) TEFDIOXINMIX | 02/17/2004 | Gavage FEMALE RATS ONLY: 0, (TCDD) 3.3, 7.3, 15.2, OR 33 NG/KG; (PeCDF) 6.6, 14.5, 30.4, OR 66 NG/KG; (PCB 126) 33.3, 73.3, 153, OR 333 NG/KG; 100/DOSE | Battelle Columbus Laboratory |
Levels of Evidence
Female Rats: Clear Evidence
Type | Organ/Tissue (Lesion) |
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Neoplastic Lesions | - Liver:
ADENOMA 0/53 1/53 1/53 1/53 11/51 OR CHOLANGIOCARCINOMA 0/53 0/53 2/53 7/53 9/51
- Lung:
CYSTIC KERATINIZING EPITHELIOMA 0/53 0/53 0/53 2/53 20/53
|
May Have Been Related | - Pancreas Acinar Cell:
ADENOMA OR CARCINOMA 0/52 1/53 2/53 2/53 0/51
|
Non-Neoplastic Lesions | - LIVER: HEPATOCYTE HYPERTROPHY; MULTINUCLEATED HEPATOCYTE; PIGMENTATION; INFLAMMATION; DIFFUSE FATTY CHANGE; BILE DUCT HYPERPLASIA; OVAL CELL HYPERPLASIA; NODULAR HYPERPLASIA; EOSINOPHILIC FOCUS; CHOLANGIOFIBROSIS; BILE DUCT CYST; NECROSIS; PORTAL FIBROSIS; MIXED CELL FOCUS; TOXIC HEPATOPATHY
- LUNG: ALVEOLAR EPITHELIUM, METAPLASIA, BRONCHIOLAR; SQUAMOUS METAPLASIA
- PANCREAS: ARTERIAL CHRONIC ACTIVE INFLAMMATION; ACINAR CYTOPLASMIC VACUOLIZATION; ACINAR ATROPHY; CHRONIC ACTIVE INFLAMMATION; DUCT DILATATION
- ADRENAL CORTEX: HYPERPLASIA; CYSTIC DEGENERATION; ATROPHY; CYTOPLASMIC VACUOLIZATION
- ORAL MUCOSA: GINGIVAL SQUAMOUS HYPERPLASIA
- UTERUS: SQUAMOUS METAPLASIA
- THYMUS: ATROPHY; SEVERITY OF ATROPHY
- OVARY: CHRONIC ACTIVE INFLAMMATION
- KIDNEY: NEPHROPATHY; SEVERITY OF NEPHROPATHY
- HEART: CARDIOMYOPATHY
- BONE MARROW: HYPERPLASIA
- URINARY BLADDER: TRANSITIONAL EPITHELIAL HYPERPLASIA
- MESENTERY: ARTERIAL CHRONIC ACTIVE INFLAMMATION
- THYROID GLAND: FOLLICULAR CELL HYPERTROPHY
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