Toxic equivalency factor evaluation (Binary mixture; PCB 126/PCB 153): Target Organs and Levels of Evidence for TR-530
Toxicology and Carcinogenesis Studies of a Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) and 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) (CASRN 35065-27-1) in Female Harlan Sprague-Dawley Rats (Gavage Studies)
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
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TEF evaluation (Binary mixture; PCB 126/PCB 153) TEFBINARYMIX | 12/09/2004 | Gavage FEMALE RATS ONLY: 0; (PCB126) 10, 100, 300, OR 1000 NG/KG; (PCB 153) 10, 100, 300, OR 1000 UG/KG; 50/DOSE | Battelle Columbus Laboratory |
Levels of Evidence
Female Rats: Clear Evidence
Type | Organ/Tissue (Lesion) |
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Neoplastic Lesions | - Liver:
CHOLANGIOCARCINOMA 0/53 0/53 1/52 9/52 30/51 HEPATOCHOLANGIOMA 0/53 0/53 0/52 2/52 6/51 ADENOMA 0/53 0/53 3/52 5/52 27/51
- Lung:
CYSTIC KERATINIZING EPITHELIOMA 0/53 0/53 0/52 1/53 11/52
- Oral Cavity:
SQUAMOUS CELL CARCINOMA (GINGIVAL) 0/53 0/53 2/53 5/53 9/53
- Pancreas Acinar Cell:
ADENOMA 0/53 1/53 1/52 3/52 1/50 ADENOMA OR CARCINOMA 0/53 1/53 1/52 4 /52 2/50
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May Have Been Related | - Uterus/Cervix:
SQUAMOUS CELL CARCINOMA 1/53 1/53 1/53 4/53 0/53
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Non-Neoplastic Lesions | - LIVER: HEPATOCYTE HYPERTROPHY; MULTINUCLEATED HEPATOCYTE; PIGMENTATION; DIFFUSE FATTY CHANGE; FOCAL FATTY CHANGE; EOSINOPHILIC FOCUS; TOXIC HEPATOPATHY; BILE DUCT CYST; BILE DUCT HYPERPLASIA; NECROSIS; OVAL CELL HYPERPLASIA; PORTAL FIBROSIS; NODULAR HYPERPLASIA, CHOLANGIOFIBROSIS
- LUNG: SQUAMOUS METAPLASIA; ALVEOLAR EPITHELIUM METAPLASIA; BRONCHIOLAR METAPLASIA
- ORAL CAVITY: GINGIVAL SQUAMOUS HYPERPLASIA
- PANCREAS: ACINAR CYTOPLASMIC VACUOLIZATION; ACINAR ATROPHY
- ADRENAL CORTEX: ATROPHY; HYPERPLASIA
- THYROID GLAND: FOLLICULAR CELL HYPERTROPHY
- THYMUS: ATROPHY
- KIDNEY: SEVERITY OF NEPHROPATHY; PIGMENTATION
- NASAL CAVITY: RESPIRATORY EPITHELIUM HYPERPLASIA; OLFACTORY EPITHELIUM METAPLASIA
- FORESTOMACH: SQUAMOUS HYPERPLASIA
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