Target Organs and Levels of Evidence for TR-530
Toxicology and Carcinogenesis Studies of a Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) and 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) (CASRN 35065-27-1) in Female Harlan Sprague-Dawley Rats (Gavage Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
TEF evaluation (Binary mixture; PCB 126/PCB 153)
TEFBINARYMIX |
12/09/2004 |
Gavage
FEMALE RATS ONLY: 0; (PCB126) 10, 100, 300, OR 1000 NG/KG; (PCB 153) 10, 100, 300, OR 1000 UG/KG; 50/DOSE |
Battelle Columbus Laboratory |
Levels of Evidence
Female Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: CHOLANGIOCARCINOMA 0/53 0/53 1/52 9/52 30/51 HEPATOCHOLANGIOMA 0/53 0/53 0/52 2/52 6/51 ADENOMA 0/53 0/53 3/52 5/52 27/51
- Lung: CYSTIC KERATINIZING EPITHELIOMA 0/53 0/53 0/52 1/53 11/52
- Oral Cavity: SQUAMOUS CELL CARCINOMA (GINGIVAL) 0/53 0/53 2/53 5/53 9/53
- Pancreas Acinar Cell: ADENOMA 0/53 1/53 1/52 3/52 1/50 ADENOMA OR CARCINOMA 0/53 1/53 1/52 4 /52 2/50
|
| May Have Been Related |
- Uterus/Cervix: SQUAMOUS CELL CARCINOMA 1/53 1/53 1/53 4/53 0/53
|
| Non-Neoplastic Lesions |
- LIVER: HEPATOCYTE HYPERTROPHY; MULTINUCLEATED HEPATOCYTE; PIGMENTATION; DIFFUSE FATTY CHANGE; FOCAL FATTY CHANGE; EOSINOPHILIC FOCUS; TOXIC HEPATOPATHY; BILE DUCT CYST; BILE DUCT HYPERPLASIA; NECROSIS; OVAL CELL HYPERPLASIA; PORTAL FIBROSIS; NODULAR HYPERPLASIA, CHOLANGIOFIBROSIS
- LUNG: SQUAMOUS METAPLASIA; ALVEOLAR EPITHELIUM METAPLASIA; BRONCHIOLAR METAPLASIA
- ORAL CAVITY: GINGIVAL SQUAMOUS HYPERPLASIA
- PANCREAS: ACINAR CYTOPLASMIC VACUOLIZATION; ACINAR ATROPHY
- ADRENAL CORTEX: ATROPHY; HYPERPLASIA
- THYROID GLAND: FOLLICULAR CELL HYPERTROPHY
- THYMUS: ATROPHY
- KIDNEY: SEVERITY OF NEPHROPATHY; PIGMENTATION
- NASAL CAVITY: RESPIRATORY EPITHELIUM HYPERPLASIA; OLFACTORY EPITHELIUM METAPLASIA
- FORESTOMACH: SQUAMOUS HYPERPLASIA
|
