Target Organs and Levels of Evidence for TR-531
Toxicology and Carcinogenesis Studies of a Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) and 2,3',4,4',5-Pentachlorobiphenyl (PCB 118) (CASRN 31508-00-6) in Female Harlan Sprague-Dawley Rats (Gavage Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Primary Uses |
Route/Exposure Levels |
Study Laboratory |
TEF Evaluation (PCB Mixture; PCB 126/PCB 118) TEFPCBMIX |
12/09/2004 |
One of 2 dioxin-like compounds plus mixtures being tested to determine if the TEFs for these chemicals would be predictive of rodent carcinogenicity. This mixture consists of PCB 118 (2,3',4,4',5- pentachlorobiphenyl) & PCB 126 (3,3',4,4',5- pentachlorobiphenyl) Mixtures were produced commercially before 1977 for the electric industry as dielectric insulating fluids for transformers & capacitors |
Gavage Female rats only (PCB 118/PCB 126): 0, 7, 22, 72, 216, or 360 ng/kg; 50/dose |
Battelle Columbus Laboratory |
Levels of Evidence
Female Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: Cholangiocarcinoma 0/53 0/51 5/53 19/53 28/53 12/65 19/50 adenoma 2/53 1/51 0/53 4/53 17/53 5/65 1/50 carcinoma 0/53 0/51 0/53 0/53 1/53 0/65 0/50
- Lung: Cystic keratinizing epithelioma 0/53 0/51 0/53 20/53 49/53 41/66 12/50
- Oral Cavity: Gingival squamous cell carcinoma 1/53 1/51 2/53 4/53 0/53 1/66 1/50
|
May Have Been Related |
- Liver: Hepatocholangioma 0/53 0/51 0/53 1/53 1/53 1/65 1/50 cholangioma 0/53 0/51 0/53 1/53 0/53 0/65 0/50
|
Non-Neoplastic Lesions |
- Liver: hepatocyte hypertrophy; multinucleated hepatocyte; hepatocyte glandular structure; pigmentation; toxic hepatopathy; diffuse fatty change; nodular hyperplasia; centrilobular fibrosis; necrosis; oval cell hyperplasia; bile duct cyst; bile duct hyperplasia; portal fibrosis; cholangiofibrosis; eosinophilic focus; focal fatty change; centrilobular degeneration; metaplasia
- Lung: alveolar epithelium metaplasia bronchiolar; squamous metaplasia; serosal fibrosis; keratin cyst
- Oral cavity: gingival squamous hyperplasia
- Thymus: atrophy; severity of atrophy
- Thyroid gland: follicular cell hypertrophy
- Adrenal cortex: atrophy; cytoplasmic vacuolization
- Pancreas: acinus cytoplasmic vacuolization; chronic active artery inflammation; acinus atrophy; chronic active inflammation
- Kidney: nephropathy; severity of nephropathy
- Heart: cardiomyopathy; coronary artery chronic active inflammation; epicardium inflammation
- Mandibular lymph node: hemorrhage
- Mediastinal lymph node: hemorrhage
- Mesenteric lymph node: hemorrhage
- Mesentery: artery chronic active inflammation
- Brain: hemorrhage
- Forestomach: squamous hyperplasia
- Spleen: lymphoid follicle atrophy
- Nasal cavity: inflammation; respiratory epithelium hyperplasia; olfactory epithelium metaplasia
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