Target Organs and Levels of Evidence for TR-531
Toxicology and Carcinogenesis Studies of a Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) and 2,3',4,4',5-Pentachlorobiphenyl (PCB 118) (CASRN 31508-00-6) in Female Harlan Sprague-Dawley Rats (Gavage Studies)
Chemical (Study Title) CASRN |
Peer Review Date | Primary Uses | Route/Exposure Levels | Study Laboratory |
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TEF Evaluation (PCB Mixture; PCB 126/PCB 118) TEFPCBMIX |
12/09/2004 | One of 2 dioxin-like compounds plus mixtures being tested to determine if the TEFs for these chemicals would be predictive of rodent carcinogenicity. This mixture consists of PCB 118 (2,3',4,4',5- pentachlorobiphenyl) & PCB 126 (3,3',4,4',5- pentachlorobiphenyl) Mixtures were produced commercially before 1977 for the electric industry as dielectric insulating fluids for transformers & capacitors | Gavage Female rats only (PCB 118/PCB 126): 0, 7, 22, 72, 216, or 360 ng/kg; 50/dose |
Battelle Columbus Laboratory |
Levels of Evidence
Female Rats: Clear Evidence
Type | Organ/Tissue (Lesion) |
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Neoplastic Lesions |
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May Have Been Related |
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Non-Neoplastic Lesions |
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