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Target Organs and Levels of Evidence for TR-533

Toxicology and Carcinogenesis Studies of Benzophenone (CASRN 119-61-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Benzophenone 119-61-9	12/09/2004	Dosed-Feed R&M: 0, 312, 625, OR 1250 PPM; 50/SEX/DOSE	Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Some Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Kidney Tubular Cell: ADENOMA (STANDARD EVALUATION) 1/50 1/50 2/50 4/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 2/50 2/50 7/50 8/50
May Have Been Related	Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 27/50 41/50 39/50 24/50
Non-Neoplastic Lesions	KIDNEY: HYPERPLASIA; PELVIS TRANSITIONAL EPITHELIUM HYPERPLASIA; SEVERITY OF NEPHROPATHY LIVER: HEPATOCYTE; CENTRILOBULAR HYPERTROPHY; CYSTIC DEGENERATION

Female Rats: Equivocal Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 19/50 25/50 30/50 29/50; HISTIOCYTIC SARCOMA 0/50 0/50 1/50 2/50
Non-Neoplastic Lesions	KIDNEY: HYPERPLASIA; SEVERITY OF NEPHROPATHY LIVER: HEPATOCYTE CENTRILOBULAR HYPERTROPHY; BILE DUCT HYPERPLASIA
Other Considerations	MAMMARY GLAND: FIBROADENOMA 27/50 24/50 15/50 7/50

Male Mice: Some Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: ADENOMA 11/50 15/50 23/50 23/50 ADENOMA, CARCINOMA, OR HEPATOBLASTOMA 18/50 20/50 25/50 29/50
Non-Neoplastic Lesions	LIVER: HEPATOCYTE CENTRILOBULAR HYPERTROPHY; MULTINUCLEATED HEPATOCYTE; ACTIVE CHRONIC INFLAMMATION; CYSTIC DEGENERATION KIDNEY: SEVERITY OF NEPHROPATHY NASAL CAVITY: OLFACTORY EPITHELIIUM; METAPLASIA SPLEEN: LYMPHOID FOLLICLE HYPERPLASIA

Female Mice: Some Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Hematopoietic System: HISTIOCYTIC SARCOMA: 0/50 0/50 5/50 3/50
May Have Been Related	Liver: ADENOMA 5/50 4/50 10/50 8/50
Non-Neoplastic Lesions	LIVER: HEPATOCYTE CENTRILOBULAR HYPERTROPHY KIDNEY: NEPHROPATHY; SEVERITY OF NEPHROPATHY; MINERALIZATION NASAL CAVITY: OLFACTORY EPITHELIUM METAPLASIA SPLEEN: LYMPHOID FOLLICLE HYPERPLASIA