Skip to Main Navigation
Skip to Page Content
COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/489

Target Organs and Levels of Evidence for TR-533

Toxicology and Carcinogenesis Studies of Benzophenone (CASRN 119-61-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Benzophenone
119-61-9		 12/09/2004 Dosed-Feed
R&M: 0, 312, 625, OR 1250 PPM; 50/SEX/DOSE		 Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA (STANDARD EVALUATION) 1/50 1/50 2/50 4/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 2/50 2/50 7/50 8/50
May Have Been Related
  • Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 27/50 41/50 39/50 24/50
Non-Neoplastic Lesions
  • KIDNEY: HYPERPLASIA; PELVIS TRANSITIONAL EPITHELIUM HYPERPLASIA; SEVERITY OF NEPHROPATHY
  • LIVER: HEPATOCYTE; CENTRILOBULAR HYPERTROPHY; CYSTIC DEGENERATION
Female Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 19/50 25/50 30/50 29/50; HISTIOCYTIC SARCOMA 0/50 0/50 1/50 2/50
Non-Neoplastic Lesions
  • KIDNEY: HYPERPLASIA; SEVERITY OF NEPHROPATHY
  • LIVER: HEPATOCYTE CENTRILOBULAR HYPERTROPHY; BILE DUCT HYPERPLASIA
Other Considerations
  • MAMMARY GLAND: FIBROADENOMA 27/50 24/50 15/50 7/50
Male Mice: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 11/50 15/50 23/50 23/50 ADENOMA, CARCINOMA, OR HEPATOBLASTOMA 18/50 20/50 25/50 29/50
Non-Neoplastic Lesions
  • LIVER: HEPATOCYTE CENTRILOBULAR HYPERTROPHY; MULTINUCLEATED HEPATOCYTE; ACTIVE CHRONIC INFLAMMATION; CYSTIC DEGENERATION
  • KIDNEY: SEVERITY OF NEPHROPATHY
  • NASAL CAVITY: OLFACTORY EPITHELIIUM; METAPLASIA
  • SPLEEN: LYMPHOID FOLLICLE HYPERPLASIA
Female Mice: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: HISTIOCYTIC SARCOMA: 0/50 0/50 5/50 3/50
May Have Been Related
  • Liver: ADENOMA 5/50 4/50 10/50 8/50
Non-Neoplastic Lesions
  • LIVER: HEPATOCYTE CENTRILOBULAR HYPERTROPHY
  • KIDNEY: NEPHROPATHY; SEVERITY OF NEPHROPATHY; MINERALIZATION
  • NASAL CAVITY: OLFACTORY EPITHELIUM METAPLASIA
  • SPLEEN: LYMPHOID FOLLICLE HYPERPLASIA