Benzophenone: Target Organs and Levels of Evidence for TR-533
Toxicology and Carcinogenesis Studies of Benzophenone (CASRN 119-61-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Benzophenone
119-61-9 | 12/09/2004 | Dosed-Feed
R&M: 0, 312, 625, OR 1250 PPM; 50/SEX/DOSE | Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Kidney Tubular Cell:
ADENOMA (STANDARD EVALUATION) 1/50 1/50 2/50 4/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 2/50 2/50 7/50 8/50
|
| May Have Been Related | - Hematopoietic System:
MONONUCLEAR CELL LEUKEMIA 27/50 41/50 39/50 24/50
|
| Non-Neoplastic Lesions | - KIDNEY: HYPERPLASIA; PELVIS TRANSITIONAL EPITHELIUM HYPERPLASIA; SEVERITY OF NEPHROPATHY
- LIVER: HEPATOCYTE; CENTRILOBULAR HYPERTROPHY; CYSTIC DEGENERATION
|
Female Rats: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Hematopoietic System:
MONONUCLEAR CELL LEUKEMIA 19/50 25/50 30/50 29/50; HISTIOCYTIC SARCOMA 0/50 0/50 1/50 2/50
|
| Non-Neoplastic Lesions | - KIDNEY: HYPERPLASIA; SEVERITY OF NEPHROPATHY
- LIVER: HEPATOCYTE CENTRILOBULAR HYPERTROPHY; BILE DUCT HYPERPLASIA
|
| Other Considerations | - MAMMARY GLAND: FIBROADENOMA 27/50 24/50 15/50 7/50
|
Male Mice: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
ADENOMA 11/50 15/50 23/50 23/50 ADENOMA, CARCINOMA, OR HEPATOBLASTOMA 18/50 20/50 25/50 29/50
|
| Non-Neoplastic Lesions | - LIVER: HEPATOCYTE CENTRILOBULAR HYPERTROPHY; MULTINUCLEATED HEPATOCYTE; ACTIVE CHRONIC INFLAMMATION; CYSTIC DEGENERATION
- KIDNEY: SEVERITY OF NEPHROPATHY
- NASAL CAVITY: OLFACTORY EPITHELIIUM; METAPLASIA
- SPLEEN: LYMPHOID FOLLICLE HYPERPLASIA
|
Female Mice: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Hematopoietic System:
HISTIOCYTIC SARCOMA: 0/50 0/50 5/50 3/50
|
| May Have Been Related | - Liver:
ADENOMA 5/50 4/50 10/50 8/50
|
| Non-Neoplastic Lesions | - LIVER: HEPATOCYTE CENTRILOBULAR HYPERTROPHY
- KIDNEY: NEPHROPATHY; SEVERITY OF NEPHROPATHY; MINERALIZATION
- NASAL CAVITY: OLFACTORY EPITHELIUM METAPLASIA
- SPLEEN: LYMPHOID FOLLICLE HYPERPLASIA
|
