Target Organs and Levels of Evidence for TR-533
Toxicology and Carcinogenesis Studies of Benzophenone (CASRN 119-61-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Benzophenone 119-61-9 |
12/09/2004 |
Dosed-Feed R&M: 0, 312, 625, OR 1250 PPM; 50/SEX/DOSE |
Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Kidney Tubular Cell: ADENOMA (STANDARD EVALUATION) 1/50 1/50 2/50 4/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 2/50 2/50 7/50 8/50
|
May Have Been Related |
- Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 27/50 41/50 39/50 24/50
|
Non-Neoplastic Lesions |
- KIDNEY: HYPERPLASIA; PELVIS TRANSITIONAL EPITHELIUM HYPERPLASIA; SEVERITY OF NEPHROPATHY
- LIVER: HEPATOCYTE; CENTRILOBULAR HYPERTROPHY; CYSTIC DEGENERATION
|
Female Rats: Equivocal Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 19/50 25/50 30/50 29/50; HISTIOCYTIC SARCOMA 0/50 0/50 1/50 2/50
|
Non-Neoplastic Lesions |
- KIDNEY: HYPERPLASIA; SEVERITY OF NEPHROPATHY
- LIVER: HEPATOCYTE CENTRILOBULAR HYPERTROPHY; BILE DUCT HYPERPLASIA
|
Other Considerations |
- MAMMARY GLAND: FIBROADENOMA 27/50 24/50 15/50 7/50
|
Male Mice: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: ADENOMA 11/50 15/50 23/50 23/50 ADENOMA, CARCINOMA, OR HEPATOBLASTOMA 18/50 20/50 25/50 29/50
|
Non-Neoplastic Lesions |
- LIVER: HEPATOCYTE CENTRILOBULAR HYPERTROPHY; MULTINUCLEATED HEPATOCYTE; ACTIVE CHRONIC INFLAMMATION; CYSTIC DEGENERATION
- KIDNEY: SEVERITY OF NEPHROPATHY
- NASAL CAVITY: OLFACTORY EPITHELIIUM; METAPLASIA
- SPLEEN: LYMPHOID FOLLICLE HYPERPLASIA
|
Female Mice: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Hematopoietic System: HISTIOCYTIC SARCOMA: 0/50 0/50 5/50 3/50
|
May Have Been Related |
- Liver: ADENOMA 5/50 4/50 10/50 8/50
|
Non-Neoplastic Lesions |
- LIVER: HEPATOCYTE CENTRILOBULAR HYPERTROPHY
- KIDNEY: NEPHROPATHY; SEVERITY OF NEPHROPATHY; MINERALIZATION
- NASAL CAVITY: OLFACTORY EPITHELIUM METAPLASIA
- SPLEEN: LYMPHOID FOLLICLE HYPERPLASIA
|