Divinylbenzene: Target Organs and Levels of Evidence for TR-534
Toxicology and Carcinogenesis Studies of Divinylbenzene-HP (CASRN 1321-74-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Divinylbenzene
1321-74-0 | 09/27/2005 | Inhalation
R: 0, 100, 200, OR 400 PPM M: 0, 10, 30, OR 100 PPM | Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Kidney Tubular Cell:
CARCINOMA (STANDARD EVALUATION) 0/50 0/49 0/50 2/49 ADENOMA OR CARCINOMA (STANDARD AND EXTENDED EVALUATIONS) 0/50 0/49 2/50 3/49
- Brain:
OLIGODENDROGLIOMA OR ASTROCYTOMA 0/49 1/50 3/50 0/50
|
| Non-Neoplastic Lesions | - NASAL CAVITY: EPITHELIAL DEGENERATION; BASAL CELL EPITHELIAL HYPERPLASIA; GLANDULAR DILATATION; GOBLET CELL HYPERPLASIA
|
Female Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - NASAL CAVITY: EPITHELIAL DEGENERATION; BASAL CELL EPITHELIAL HYPERPLASIA
|
Male Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - LUNG: ATYPICAL BRONCHIOLAR HYPERPLASIA; ALVEOLAR EPITHELIAL HYPERPLASIA
- NASAL CAVITY: SUPPURATIVE INFLAMMATION; GLANDULAR RESPIRATORY EPITHELIAL METAPLASIA; EPITHELIAL RESPIRATORY METAPLASIA; HYALINE EPITHELIAL DEGENERATION
|
Female Mice: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Lung:
ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 6/50 12/50 8/50 13/49
|
| Non-Neoplastic Lesions | - LUNG: ATYPICAL BRONCHIOLAR HYPERPLASIA; ALVEOLAR EPITHELIAL HYPERPLASIA
- NASAL CAVITY: SUPPURATIVE INFLAMMATION; GLANDULAR RESPIRATORY EPITHELIAL METAPLASIA; EPITHELIAL RESPIRATORY METAPLASIA; HYALINE EPITHELIAL DEGENERATION
|
