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Target Organs and Levels of Evidence for TR-534

Toxicology and Carcinogenesis Studies of Divinylbenzene-HP (CASRN 1321-74-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review Date Route/Exposure Levels Study Laboratory
Divinylbenzene
1321-74-0
09/27/2005 Inhalation
R: 0, 100, 200, OR 400 PPM M: 0, 10, 30, OR 100 PPM
Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: CARCINOMA (STANDARD EVALUATION) 0/50 0/49 0/50 2/49 ADENOMA OR CARCINOMA (STANDARD AND EXTENDED EVALUATIONS) 0/50 0/49 2/50 3/49
  • Brain: OLIGODENDROGLIOMA OR ASTROCYTOMA 0/49 1/50 3/50 0/50
Non-Neoplastic Lesions
  • NASAL CAVITY: EPITHELIAL DEGENERATION; BASAL CELL EPITHELIAL HYPERPLASIA; GLANDULAR DILATATION; GOBLET CELL HYPERPLASIA
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: EPITHELIAL DEGENERATION; BASAL CELL EPITHELIAL HYPERPLASIA
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: ATYPICAL BRONCHIOLAR HYPERPLASIA; ALVEOLAR EPITHELIAL HYPERPLASIA
  • NASAL CAVITY: SUPPURATIVE INFLAMMATION; GLANDULAR RESPIRATORY EPITHELIAL METAPLASIA; EPITHELIAL RESPIRATORY METAPLASIA; HYALINE EPITHELIAL DEGENERATION
Female Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 6/50 12/50 8/50 13/49
Non-Neoplastic Lesions
  • LUNG: ATYPICAL BRONCHIOLAR HYPERPLASIA; ALVEOLAR EPITHELIAL HYPERPLASIA
  • NASAL CAVITY: SUPPURATIVE INFLAMMATION; GLANDULAR RESPIRATORY EPITHELIAL METAPLASIA; EPITHELIAL RESPIRATORY METAPLASIA; HYALINE EPITHELIAL DEGENERATION