4-Methylimidazole: Target Organs and Levels of Evidence for TR-535
Toxicology and Carcinogenesis Studies of 4-Methylimidazole (CASRN 822-36-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
4-Methylimidazole
822-36-6 | 09/28/2005 | Dosed-Feed
MR: 0, 625, 1250, OR 2500 PPM; FR: 0, 1250, 2500, OR 5000 PPM; M: 0, 312, 625, OR 1250 PPM; 50/SEX/SPECIES/GROUP | Southern Research Institute |
Levels of Evidence
Male Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - LIVER: HISTIOCYTOSIS; CHRONIC INFLAMMATION; HEPATOCYTIC FOCAL FATTY CHANGE; EOSINOPHILIC FOCUS; MIXED CELL FOCUS
|
Female Rats: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Hematopoietic System:
MONONUCLEAR CELL LEUKEMIA 9/50 7/50 16/50 20/50
|
| Non-Neoplastic Lesions | - LIVER: HISTIOCYTOSIS; CHRONIC INFLAMMATION; HEPATOCYTIC FOCAL FATTY CHANGE; EOSINOPHILIC FOCUS; MIXED CELL FOCUS
|
Male Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Lung:
ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 4/50 4/50 8/50 ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA (COMBINED) 9/50 13/50 16/50 22/50
|
Female Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Lung:
ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 8/50 16/50 8/50 ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 0/50 2/50 7/50 COMBINED 3/50 8/50 17/50 14/50
|
| Non-Neoplastic Lesions | - LUNG: ALVEOLAR EPITHELIAL HYPERPLASIA
|
