bis(2-Chloroethoxy)methane: Target Organs and Levels of Evidence for TR-536
Toxicology and Carcinogenesis Studies of bis(2-Chloroethoxy)methane (CAS No. 111-91-1) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
bis(2-Chloroethoxy)methane
111-91-1 | 11/19/2009 | Topical Application
R: 0, 75, 150, OR 300 MG/KG; MM: 0, 150, 300 OR 600 MG/KG; FM: 0, 100, 200, OR 400 MG/KG | Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - Nasal Cavity: Olfactory epithelium, degeneration
- Forestomach: Inflammation; ulcer
|
Female Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - Nasal Cavity: Olfactory epithelium, degeneration
|
Male Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - Heart: Cardiomyopathy; myocardium, fibrosis; infiltration cellular, mononuclear cell; vacuolization cytoplasmic
- Forestomach: Ulcer
- Skin: Dermis, fibrosis, inflammation; epidermis, hyperplasia
|
Female Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - Heart: Cardiomyopathy; myocardium, infiltration cellular, mononuclear cell; vacuolization cytoplasmic
|
