Target Organs and Levels of Evidence for TR-537
Toxicology and Carcinogenesis Studies of Dibromoacetic Acid (CASRN 631-64-1) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Water disinfection byproducts (Dibromoacetic acid)
631-64-1 |
09/27/2005 |
Dosed-Water
R&M: 0, 50, 500, OR 1000 MG/L; 50/SEX/SPECIES |
Southern Research Institute |
Levels of Evidence
Male Rats: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Hematopoietic System: MALIGNANT MESOTHELIOMA (ALL ORGANS) 3/50 1/50 0/50 10/50
|
| Non-Neoplastic Lesions |
- LIVER: CYSTIC DEGENERATION
|
Female Rats: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Hematopoietic System: MONONUCLEAR CELL LEUKEMIA (ALL ORGANS) 11/50 13/50 16/50 22/50
|
| Non-Neoplastic Lesions |
- LUNG: ALVEOLAR EPITHELIAL HYPERPLASIA
- KIDNEY: NEPHROPATHY
|
Male Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 18/49 37/50 37/50 42/50 CARCINOMA 14/49 9/50 19/50 26/50 COMBINED 28/49 41/50 42/50 47/50 HEPATOBLASTOMA 0/49 4/50 6/50 18/50
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 7/49 5/50 17/50 12/50 ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 12/49 12/50 22/50 17/50
|
| Non-Neoplastic Lesions |
|
Female Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 19/49 26/50 32/50 35/49 CARCINOMA 3/49 3/50 12/50 8/49 COMBINED 22/49 28/50 37/50 37/49
|
| May Have Been Related |
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 3/50 3/50 6/50 ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 2/50 5/50 5/50 7/50
|
