Target Organs and Levels of Evidence for TR-538
Toxicology and Carcinogenesis Studies of Methyl Isobutyl Ketone (CASRN 108-10-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Methyl isobutyl ketone 108-10-1 |
09/27/2005 |
Inhalation R&M: 0, 450, 900, OR 1800 PPM |
Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Kidney Tubular Cell: ADENOMA (STANDARD EVALUATION - 0/50 0/50 2/50 3/50; STANDARD AND EXTENDED EVAULATION COMBINED - 2/50 3/50 3/50 10/50); CARCINOMA (STANDARD EVALUATION - 0/50 1/50 0/50 2/50); ADENOMA OR CARCINOMA (COMBINED) (STANDARD EVAULATION - 0/50 1/50 2/50 4/50; STANDARD AND EXTENDED EVALUATION - 2/50 4/50 3/50 11/50)
|
May Have Been Related |
- Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 25/50 26/50 32/50 35/50
|
Non-Neoplastic Lesions |
- KIDNEY: TUBULE HYPERPLASIA; INCREASED SEVERITY OF NEPHROPATHY; PELVIS TRANSITIONAL EPITHELIAL HYPERPLASIA; PAPILLA MINERALIZATION
- ADRENAL GLAND: ADRENAL MEDULLA HYPERPLASIA
|
Female Rats: Equivocal Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Kidney Mesenchymal Cell: TUMOR MALIGNANT 0/50 0/50 0/50 2/50
|
Non-Neoplastic Lesions |
|
Male Mice: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: ADENOMA 17/50 25/50 23/50 34/50 ADENOMA OR CARCINOMA (COMBINED) 27/50 34/50 28/50 37/50
|
Female Mice: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: ADENOMA 13/50 15/50 20/50 23/50 ADENOMA OR CARCINOMA (COMBINED) 17/50 17/50 22/50 27/50
|