Methylene blue trihydrate: Target Organs and Levels of Evidence for TR-540
Toxicology and Carcinogenesis Studies of Methylene Blue Trihydrate (CASRN 7220-79-3) in F344/N Rats and B6C3F1 Mice (gavage studies)
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
---|
Methylene blue trihydrate 7220-79-3 | 06/12/2006 | Gavage R: 0, 5, 25, OR 50 MG/KG; M: 0, 2.5, 12.5, OR 25 MG/KG; 50/SEX/SPECIES | Southern Research Institute |
Levels of Evidence
Male Rats: Some Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Pancreas Islet Cell:
ADENOMA 4/50 9/50 12/50 8/50 ADENOMA OR CARCINOMA 4/50 9/50 14/50 8/50
|
Non-Neoplastic Lesions | - PANCREATIC ISLETS: HYPERPLASIA
- SPLEEN: HEMATOPOIETIC CELL PROLIFERATION, CAPSULE FIBROSIS
|
Female Rats: No Evidence
Type | Organ/Tissue (Lesion) |
---|
Non-Neoplastic Lesions | |
Male Mice: Some Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Intestines:
(SMALL) CARCINOMA 0/50 1/50 2/50 4/50 ADENOMA OR CARCINOMA 1/50 2/50 4/50 6/50
|
May Have Been Related | - Hematopoietic System:
MALIGNANT LYMPHOMA 2/50 2/50 2/50 5/50
|
Non-Neoplastic Lesions | - SPLEEN: HEMATOPOIETIC CELL PROLIFERATION
|
Female Mice: Equivocal Evidence
Type | Organ/Tissue (Lesion) |
---|
May Have Been Related | - Hematopoietic System:
MALIGNANT LYMPHOMA 6/50 4/50 9/50 12/50
|
Non-Neoplastic Lesions | - SPLEEN: HEMATOPOIETIC CELL PROLIFERATION
|