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Target Organs and Levels of Evidence for TR-540

Toxicology and Carcinogenesis Studies of Methylene Blue Trihydrate (CASRN 7220-79-3) in F344/N Rats and B6C3F1 Mice (gavage studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Methylene blue trihydrate
7220-79-3		 06/12/2006 Gavage
R: 0, 5, 25, OR 50 MG/KG; M: 0, 2.5, 12.5, OR 25 MG/KG; 50/SEX/SPECIES		 Southern Research Institute

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Pancreas Islet Cell: ADENOMA 4/50 9/50 12/50 8/50 ADENOMA OR CARCINOMA 4/50 9/50 14/50 8/50
Non-Neoplastic Lesions
  • PANCREATIC ISLETS: HYPERPLASIA
  • SPLEEN: HEMATOPOIETIC CELL PROLIFERATION, CAPSULE FIBROSIS
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • SPLEEN: CAPSULE FIBROSIS
Male Mice: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Intestines: (SMALL) CARCINOMA 0/50 1/50 2/50 4/50 ADENOMA OR CARCINOMA 1/50 2/50 4/50 6/50
May Have Been Related
  • Hematopoietic System: MALIGNANT LYMPHOMA 2/50 2/50 2/50 5/50
Non-Neoplastic Lesions
  • SPLEEN: HEMATOPOIETIC CELL PROLIFERATION
Female Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Hematopoietic System: MALIGNANT LYMPHOMA 6/50 4/50 9/50 12/50
Non-Neoplastic Lesions
  • SPLEEN: HEMATOPOIETIC CELL PROLIFERATION