Target Organs and Levels of Evidence for TR-540
Toxicology and Carcinogenesis Studies of Methylene Blue Trihydrate (CASRN 7220-79-3) in F344/N Rats and B6C3F1 Mice (gavage studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Methylene blue trihydrate 7220-79-3 |
06/12/2006 |
Gavage R: 0, 5, 25, OR 50 MG/KG; M: 0, 2.5, 12.5, OR 25 MG/KG; 50/SEX/SPECIES |
Southern Research Institute |
Levels of Evidence
Male Rats: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Pancreas Islet Cell: ADENOMA 4/50 9/50 12/50 8/50 ADENOMA OR CARCINOMA 4/50 9/50 14/50 8/50
|
Non-Neoplastic Lesions |
- PANCREATIC ISLETS: HYPERPLASIA
- SPLEEN: HEMATOPOIETIC CELL PROLIFERATION, CAPSULE FIBROSIS
|
Female Rats: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
|
Male Mice: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Intestines: (SMALL) CARCINOMA 0/50 1/50 2/50 4/50 ADENOMA OR CARCINOMA 1/50 2/50 4/50 6/50
|
May Have Been Related |
- Hematopoietic System: MALIGNANT LYMPHOMA 2/50 2/50 2/50 5/50
|
Non-Neoplastic Lesions |
- SPLEEN: HEMATOPOIETIC CELL PROLIFERATION
|
Female Mice: Equivocal Evidence
Type |
Organ/Tissue (Lesion) |
May Have Been Related |
- Hematopoietic System: MALIGNANT LYMPHOMA 6/50 4/50 9/50 12/50
|
Non-Neoplastic Lesions |
- SPLEEN: HEMATOPOIETIC CELL PROLIFERATION
|