https://ntp.niehs.nih.gov/go/LOE-TR-541

Target Organs and Levels of Evidence for TR-541

Toxicology and Carcinogenesis Studies of Formamide (CASRN 75-12-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Formamide
75-12-7		 05/16/2007 Gavage
R&M: 0, 10, 20, 40, 80, OR 160 MG/KG; 10/SEX/SPECIES/DOSE		 Battelle Columbus Laboratory

Levels of Evidence: None

 
Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Formamide
75-12-7		 05/16/2007 Gavage
R&M: 0, 20, 40, OR 80 MG/KG; 50/SEX/DOSE		 Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Bone Marrow: hyperplasia
Female Rats: No Evidence
Male Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: hemangiosarcoma (1/50, 5/50, 7/50, 8/50)
Non-Neoplastic Lesions
  • Testes: mineralization of artery; mineralization of tunic
  • Spleen: hematopoietic cell proliferation
Female Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Liver: adenoma or carcinoma 9/50, 15/50, 13/50, 18/50