Skip to Main Navigation
Skip to Page Content
COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/LOE-TR-542

Cumene: Target Organs and Levels of Evidence for TR-542

Toxicology and Carcinogenesis Studies of Cumene (CASRN 98-82-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN		Peer Review DateRoute/Exposure LevelsStudy Laboratory
Cumene
98-82-8		05/16/2007Inhalation
R: 0, 250, 500, OR 1000 PPM MM: 0, 250, 500, OR 1000 PPM FM: 0, 125, 250, OR 500 PPM 50/SEX/SPECIES		Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: respiratory epithelium, adenoma (0/50, 7/50, 18/49, 10/50)
  • Kidney Tubular Cell: renal tubule, adenoma or carcinoma (2/50, 5/50, 8/50, 7/50)
May Have Been Related
  • Testis: interstitial cell adenoma
Non-Neoplastic Lesions
  • Nasal Cavity: olfactory epithelium, hyperplasia; basal cell; respiratory epithelium, hyperplasia
  • Kidney: tubule, hyperplasia; papilla, mineralization; pelvis, transitional epithelium, hyperplasia
Female Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: respiratory epithelium, adenoma (0/50, 5/48, 4/50, 3/50)
Non-Neoplastic Lesions
  • Nasal Cavity: olfactory epithelium, hyperplasia; basal cell; respiratory epithelium, hyperplasia
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: alveolar/bronchiolar adenoma (13/50, 31/50, 31/50, 29/50); alveolar/bronchiolar carcinoma (9/50, 19/50, 32/50, 33/50); alveolar/bronchiolar adenoma or carcinoma (19/50, 38/50, 42/50, 43/50)
May Have Been Related
  • Spleen: hemangioscaroma
  • Thyroid Gland Follicular Cell: adenoma
Non-Neoplastic Lesions
  • Lung: alveolar epithelium, bronchiole, metaplasia; bronchiole, hyperplasia
  • Nasal Cavity: olfactory epithelium, atrophy; olfactory epithelium, hyperplasia, basal cell; olfactory epithelium, hyperplasia, atypical; olfactory epithelium, glands, hyperplasia; inflammation, suppurative
  • Liver: eosinophilic focus
  • Forestomach: epithelium, hyperplasia; ulcer; inflammation
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: alveolar/bronchiolar adenoma (1/50, 26/50, 36/50, 38/50); alveolar/bronchiolar carcinoma (3/50, 16/50, 20/50, 34/50); alveolar/bronchiolar adenoma or carcinoma (4/50, 31/50, 42/50, 46/50)
  • Liver: adenoma (18/50, 23/50, 27/50, 29/50); adenoma or carcinoma (25/50, 26/50, 29/50, 36/50)
Non-Neoplastic Lesions
  • Lung: alveolar epithelium, bronchiole, metaplasia; bronchiole, hyperplasia
  • Nasal Cavity: olfactory epithelium, atrophy; olfactory epithelium, hyperplasia, basal cell; olfactory epithelium, hyperplasia, atypical; olfactory epithelium, glands, hyperplasia; respiratory epithelium, metaplasia, squamous; inflammation, suppurative