Target Organs and Levels of Evidence for TR-542
Toxicology and Carcinogenesis Studies of Cumene (CASRN 98-82-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Cumene 98-82-8 |
05/16/2007 |
Inhalation R: 0, 250, 500, OR 1000 PPM MM: 0, 250, 500, OR 1000 PPM FM: 0, 125, 250, OR 500 PPM 50/SEX/SPECIES |
Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Nasal Cavity: respiratory epithelium, adenoma (0/50, 7/50, 18/49, 10/50)
- Kidney Tubular Cell: renal tubule, adenoma or carcinoma (2/50, 5/50, 8/50, 7/50)
|
May Have Been Related |
- Testis: interstitial cell adenoma
|
Non-Neoplastic Lesions |
- Nasal Cavity: olfactory epithelium, hyperplasia; basal cell; respiratory epithelium, hyperplasia
- Kidney: tubule, hyperplasia; papilla, mineralization; pelvis, transitional epithelium, hyperplasia
|
Female Rats: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Nasal Cavity: respiratory epithelium, adenoma (0/50, 5/48, 4/50, 3/50)
|
Non-Neoplastic Lesions |
- Nasal Cavity: olfactory epithelium, hyperplasia; basal cell; respiratory epithelium, hyperplasia
|
Male Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Lung: alveolar/bronchiolar adenoma (13/50, 31/50, 31/50, 29/50); alveolar/bronchiolar carcinoma (9/50, 19/50, 32/50, 33/50); alveolar/bronchiolar adenoma or carcinoma (19/50, 38/50, 42/50, 43/50)
|
May Have Been Related |
- Spleen: hemangioscaroma
- Thyroid Gland Follicular Cell: adenoma
|
Non-Neoplastic Lesions |
- Lung: alveolar epithelium, bronchiole, metaplasia; bronchiole, hyperplasia
- Nasal Cavity: olfactory epithelium, atrophy; olfactory epithelium, hyperplasia, basal cell; olfactory epithelium, hyperplasia, atypical; olfactory epithelium, glands, hyperplasia; inflammation, suppurative
- Liver: eosinophilic focus
- Forestomach: epithelium, hyperplasia; ulcer; inflammation
|
Female Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Lung: alveolar/bronchiolar adenoma (1/50, 26/50, 36/50, 38/50); alveolar/bronchiolar carcinoma (3/50, 16/50, 20/50, 34/50); alveolar/bronchiolar adenoma or carcinoma (4/50, 31/50, 42/50, 46/50)
- Liver: adenoma (18/50, 23/50, 27/50, 29/50); adenoma or carcinoma (25/50, 26/50, 29/50, 36/50)
|
Non-Neoplastic Lesions |
- Lung: alveolar epithelium, bronchiole, metaplasia; bronchiole, hyperplasia
- Nasal Cavity: olfactory epithelium, atrophy; olfactory epithelium, hyperplasia, basal cell; olfactory epithelium, hyperplasia, atypical; olfactory epithelium, glands, hyperplasia; respiratory epithelium, metaplasia, squamous; inflammation, suppurative
|