Cumene: Target Organs and Levels of Evidence for TR-542
Toxicology and Carcinogenesis Studies of Cumene (CASRN 98-82-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
---|
Cumene 98-82-8 | 05/16/2007 | Inhalation R: 0, 250, 500, OR 1000 PPM MM: 0, 250, 500, OR 1000 PPM FM: 0, 125, 250, OR 500 PPM 50/SEX/SPECIES | Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Clear Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Nasal Cavity:
respiratory epithelium, adenoma (0/50, 7/50, 18/49, 10/50)
- Kidney Tubular Cell:
renal tubule, adenoma or carcinoma (2/50, 5/50, 8/50, 7/50)
|
May Have Been Related | - Testis:
interstitial cell adenoma
|
Non-Neoplastic Lesions | - Nasal Cavity: olfactory epithelium, hyperplasia; basal cell; respiratory epithelium, hyperplasia
- Kidney: tubule, hyperplasia; papilla, mineralization; pelvis, transitional epithelium, hyperplasia
|
Female Rats: Some Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Nasal Cavity:
respiratory epithelium, adenoma (0/50, 5/48, 4/50, 3/50)
|
Non-Neoplastic Lesions | - Nasal Cavity: olfactory epithelium, hyperplasia; basal cell; respiratory epithelium, hyperplasia
|
Male Mice: Clear Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Lung:
alveolar/bronchiolar adenoma (13/50, 31/50, 31/50, 29/50); alveolar/bronchiolar carcinoma (9/50, 19/50, 32/50, 33/50); alveolar/bronchiolar adenoma or carcinoma (19/50, 38/50, 42/50, 43/50)
|
May Have Been Related | - Spleen:
hemangioscaroma
- Thyroid Gland Follicular Cell:
adenoma
|
Non-Neoplastic Lesions | - Lung: alveolar epithelium, bronchiole, metaplasia; bronchiole, hyperplasia
- Nasal Cavity: olfactory epithelium, atrophy; olfactory epithelium, hyperplasia, basal cell; olfactory epithelium, hyperplasia, atypical; olfactory epithelium, glands, hyperplasia; inflammation, suppurative
- Liver: eosinophilic focus
- Forestomach: epithelium, hyperplasia; ulcer; inflammation
|
Female Mice: Clear Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Lung:
alveolar/bronchiolar adenoma (1/50, 26/50, 36/50, 38/50); alveolar/bronchiolar carcinoma (3/50, 16/50, 20/50, 34/50); alveolar/bronchiolar adenoma or carcinoma (4/50, 31/50, 42/50, 46/50)
- Liver:
adenoma (18/50, 23/50, 27/50, 29/50); adenoma or carcinoma (25/50, 26/50, 29/50, 36/50)
|
Non-Neoplastic Lesions | - Lung: alveolar epithelium, bronchiole, metaplasia; bronchiole, hyperplasia
- Nasal Cavity: olfactory epithelium, atrophy; olfactory epithelium, hyperplasia, basal cell; olfactory epithelium, hyperplasia, atypical; olfactory epithelium, glands, hyperplasia; respiratory epithelium, metaplasia, squamous; inflammation, suppurative
|