alpha-Methylstyrene: Target Organs and Levels of Evidence for TR-543
Toxicology and Carcinogenesis Studies of ?-Methylstyrene (CASRN 98-83-9) in F344/N Rats and B6C3F1 Mice (inhalation studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
alpha-Methylstyrene
98-83-9 |
06/12/2006 |
Inhalation
R: 0, 100, 300, OR 1000 PPM M: 0, 100, 300, OR 600 PPM; 50/SEX/SPECIES |
Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Kidney Tubular Cell: ADENOMA (STANDARD EVALUATION) 0/50 0/50 1/50 0/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 1/50 2/50 2/50 5/50 ADENOMA OR CARCINOMA (STANDARD EVALUATION) 0/50 0/50 2/50 2/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 1/50 2/50 3/50 7/50
|
| May Have Been Related |
- Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 26/50 32/50 29/50 38/50
|
| Non-Neoplastic Lesions |
- KIDNEY: PAPILLA MINERALIZATION; TUBULAR HYPERPLASIA
- NASAL CAVITY: EPITHELIAL HYPERPLASIA; BASAL CELL EPITHELIAL DEGENERATION
|
Female Rats: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- NASAL CAVITY: EPITHELIAL HYPERPLASIA; BASAL CELL EPITHELIAL DEGENERATION
|
Male Mice: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| May Have Been Related |
- Liver: ADENOMA OR CARCINOMA 28/50 36/50 33/50 37/50
|
| Non-Neoplastic Lesions |
- NASAL CAVITY: EPITHELIAL METAPLASIA; BOWNAM'S GLANDS HYPERPLASIA, ATROPHY
|
Female Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 10/50 20/50 21/50 23/50 CARCINOMA 3/50 9/50 6/50 18/50 ADENOMA OR CARCINOMA 13/50 26/50 24/50 33/50
|
| Non-Neoplastic Lesions |
- LIVER: EOSINOPHILIC FOCUS
- NASAL CAVITY: EPITHELIAL METAPLASIA; BOWMAN'S GLANDS HYPERPLASIA
- KIDNEY: NEPHROPATHY, SEVERITY OF NEPHROPATHY
|
