Water disinfection byproducts (Dibromoacetonitrile): Target Organs and Levels of Evidence for TR-544
Toxicology and Carcinogenesis Studies of Dibromoacetonitrile (CASRN 3252-43-5) in F344/N Rats and B6C3F1 Mice (Drinking Water studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Water disinfection byproducts (Dibromoacetonitrile)
3252-43-5 | 02/27/2008 | Dosed-Water
R&M: 0, 50 100, OR 200 MG/L; 50 SEX/SPECIES/DOSE | Southern Research Institute |
Levels of Evidence
Male Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Oral Cavity:
Squamous cell papilloma or carcinoma 0/50 0/50 2/50 5/50
- Glandular Stomach:
Adenoma 0/50 0/50 0/50 2/50
|
| Non-Neoplastic Lesions | - Esophagus: Epithelial hyperkeratosis
|
Female Rats: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Oral Cavity:
Squamous cell papilloma 1/50 0/50 4/50 0/50
|
| May Have Been Related | - Skin:
Squamous cell papilloma, keratoacanthoma, basal cell adenoma or carcinoma 0/50 0/50 3/50 4/50
|
| Non-Neoplastic Lesions | - Esophagus: Epithelial hyperkeratosis
- Glandular Stomach: Glandular ectasia
- Tongue: Squamous epithelial hyperplasia
|
Male Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Forestomach:
Squamous cell papilloma or carcinoma 0/50 1/50 0/50 5/50
|
| May Have Been Related | - Liver:
Hepatoblastoma 1/50 7/50 3/50 2/50 adenoma, carcinoma or hepatoblastoma 37/50 46/50 43/50 42/50
|
| Non-Neoplastic Lesions | - Forestomach: Squamous epithelial hyperplasia
|
Female Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Forestomach:
Squamous cell papilloma 1/50 0/50 5/50 14/50
|
