Target Organs and Levels of Evidence for TR-545
Toxicology and Carcinogenesis Study of Genistein (CASRN 446-72-0) in Sprague-Dawley Rats (feed study)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Endocrine disruptor (Genistein)
446-72-0 |
06/12/2006 |
Dosed-Feed:
concentration in feed 0, 5, 100, 500 PPM |
National Center for Toxicological Research |
Levels of Evidence
Male Rats (F1C): No Evidence
Female Rats (F1C): Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Mammary Gland: ADENOMA OR ADENOCARCINOMA 9/54 4/50 8/50 16/49
- Pituitary Gland: ADENOMA OR CARCINOMA 38/54 40/50 34/50 46/49
|
| Other Considerations |
- Mammary Gland: FIBROADENOMA 32/54 27/50 28/50 12/49
|
Male Rats (F1T140): No Evidence
Female Rats (F1T140):Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| May Have Been Related |
- Pituitary Gland: ADENOMA OR CARCINOMA 38/54 32/49 40/50 44/50
|
Male Rats (F3T21): No Evidence
Female Rats (F3T21):Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| May Have Been Related |
- Mammary Gland: ADENOMA OR ADENOCARCINOMA 7/53 8/49 11/50 13/50
|
