https://ntp.niehs.nih.gov/go/LOE-TR-546

Target Organs and Levels of Evidence for TR-546

Toxicology and Carcinogenesis Studies of Sodium Dichromate Dihydrate (CASRN 7789-12-0) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Sodium dichromate dihydrate (VI)
7789-12-0		 05/16/2007 Sodium dichromate dihydrate is one of a number of inorganic compounds containing hexavalent chromium (Cr VI) found in drinking water source supplies as a contaminant resulting from various industrial processes including electroplating operations, leather tanning, and textile manufacturing. Intermediate; industrial chemical Dosed-Water
M/F Rats and FM: 0, 14.3, 57.3, 172, or 516 mg/l; MM: 0, 14.3, 28.6, 85.7, or 258 mg/l		 Southern Research Institute

Levels of Evidence

Male Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Oral Cavity: squamous cell carcinoma (0/50, 1/50, 0/49, 0/50, 6/49); squamous cell papilloma or carcinoma (0/50, 1/50, 0/49, 0/50, 7/49)
Non-Neoplastic Lesions
  • Liver: infiltration cellular, histiocyte
  • Intestines, Duodenum: infiltration cellular, histiocyte
  • Lymph Node, Mesenteric: infiltration cellular, histiocyte
Female Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Oral Cavity: squamous cell carcinoma (0/50, 0/50, 0/50, 2/50, 11/50); squamous cell papilloma, or carcinoma (1/50, 1/50, 0/50, 2/50, 11/50)
Non-Neoplastic Lesions
  • Liver: infiltration cellular, histiocyte
  • Intestines, Duodenum: infiltration cellular, histiocyte
  • Lymph Node, Mesenteric: infiltration cellular, histiocyte
  • Lymph Node, Pancreatic: infiltration cellular, histiocyte
Male Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Intestines: Duodenum: adenoma (1/50, 0/50, 1/50, 5/50, 15/50); Duodenum, Jejunum, or Ileum: adenoma (1/50, 1/50, 1/50, 5/50, 17/50), carcinoma (0/50, 2/50, 1/50, 3/50, 5/50), adenoma or carcinoma (1/50, 3/50, 2/50, 7/50, 20/50)
Non-Neoplastic Lesions
  • Intestines, Duodenum: epithelium, hyperplasia, diffuse; infiltration cellular, histiocyte
  • Lymph Node, Mesenteric: infiltration cellular, histiocyte
  • Lymph Node, Pancreatic: infiltration cellular, histiocyte
Female Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Intestines: Duodenum: adenoma (0/50, 0/50, 2/50, 13/50, 12/50); carcinoma (0/50, 0/50, 0/50, 1/50, 6/50); Jejunum: adenoma (0/50, 1/50, 0/50, 2/50, 5/50); Duodenum, Jejunum, or Ileum: adenoma (0/50, 1/50, 2/50, 15/50, 16/50), carcinoma (1/50, 0/50, 2/50, 3/50, 7/50), adenoma or carcinoma (1/50, 1/50, 4/50, 17/50, 22/50)
Non-Neoplastic Lesions
  • Liver: infiltration cellular, histiocyte
  • Intestines, Duodenum: epithelium, hyperplasia, diffuse; infiltration cellular, histiocyte
  • Intestines, Jejunum: epithelium, hyperplasia, diffuse; infiltration cellular, histiocyte
  • Lymph Node, Mesenteric: infiltration cellular, histiocyte
  • Lymph Node, Pancreatic: infiltration cellular, histiocyte
 
Chemical (Study Title)
CASRN		 Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Sodium dichromate dihydrate (VI)
7789-12-0		 05/16/2007 Sodium dichromate dihydrate is one of a number of inorganic compounds containing hexavalent chromium (Cr VI) found in drinking water source supplies as a contaminant resulting from various industrial processes including electroplating operations, leather tanning, and textile manufacturing. Intermediate; industrial chemical Dosed-Water
 		 Southern Research Institute

Levels of Evidence

Male Rats: Clear Evidence
Female Rats: Clear Evidence
Male Mice: Clear Evidence
Female Mice: Clear Evidence