Target Organs and Levels of Evidence for TR-549
Toxicology and Carcinogenesis Studies of Bromochloroacetic acid (CASRN 5589-96-8) in F344/N Rats and B6C3F1 Mice (Drinking water studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Water disinfection byproducts (Bromochloroacetic acid)
5589-96-8 |
02/27/2008 |
Dosed-Water
R&M: 0, 250, 500, or 1000 mg/l; 50/sex/species/dose |
Southern Research Institute |
Levels of Evidence
Male Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Mesothelium (Abdominal Cavity/Tunica Vaginalis): Malignant Mesothelioma 1/50 5/50 10/50 6/50
- Intestines: (Large): Adenoma 0/50 2/50 0/50 4/50
|
| May Have Been Related |
- Liver: Adenoma 2/50 0/50 3/50 4/50
- Pancreas Islet Cell: Adenoma 3/50 4/50 9/50 3/50
|
| Non-Neoplastic Lesions |
- Liver: Eosinophilic focus
|
Female Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Intestines: (Large): Adenoma 0/50 0/50 3/50 7/50
- Mammary Gland: Fibroadenoma, multiple 22/50 24/50 43/50 38/50
|
| May Have Been Related |
- Liver: Adenoma 0/50 0/50 0/50 3/50
|
| Non-Neoplastic Lesions |
- Liver: Eosinophilic focus; mixed cell focus
- Lung: Alveolar epithelium hyperplasia
|
Male Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: Adenoma 27/50 40/50 40/50 31/50 carcinoma 19/50 25/50 36/50 45/50 adenoma or carcinoma 34/50 44/50 49/50 49/50 hepatoblastoma 4/50 11/50 28/50 34/50
|
| Non-Neoplastic Lesions |
- Liver: Hepatocyte cytoplasmic vacuolization; centrilobular necrosis
|
Female Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: Adenoma 27/50 48/50 44/50 46/50 carcinoma 14/50 23/50 26/50 20/50 adenoma or carcinoma 31/50 49/50 46/50 46/50
|
| Non-Neoplastic Lesions |
- Liver: Hepatocyte cytoplasmic vacuolization; eosinophilic focus
|
