Target Organs and Levels of Evidence for TR-550
Toxicology and Carcinogenesis Studies of Cresols (CASRN 1319-77-3) in Male F344/N Rats and Female B6C3F1 Mice (Feed Studies)
Chemical (Study Title) CASRN |
Peer Review Date | Primary Uses | Route/Exposure Levels | Study Laboratory |
---|---|---|---|---|
Cresols 1319-77-3 |
05/17/2007 | Household disinfectant, paintbrush cleaner, in lubricating oils, fumigant, photographic developers, explosives, organic intermediate in production of coumarin, salicylaldehyde, synthetic resins, degreasing compounds, obtained from coal tar (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products. | Dosed-Feed R: 0, 1500, 5000, or 15,000 ppm and M: 0, 1000, 3000, or 10,000 ppm; 50/species/dose |
Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: Equivocal Evidence
Type | Organ/Tissue (Lesion) |
---|---|
May Have Been Related |
|
Non-Neoplastic Lesions |
|
Female Mice: Some Evidence
Type | Organ/Tissue (Lesion) |
---|---|
Neoplastic Lesions |
|
Non-Neoplastic Lesions |
|