Isoeugenol: Target Organs and Levels of Evidence for TR-551
NTP Toxicology and Carcinogenesis Studies of Isoeugenol (CASRN 97-54-1) in F344/N Rats and B6C3F1 Mice (Gavage studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Isoeugenol
97-54-1 | 02/27/2008 | Gavage
R&M: 0, 75, 150, OR 300 MG/KG; 50/SEX/SPECIES/DOSE | Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| May Have Been Related | - Thymus:
Thymoma, benign or malignant 0/47 0/43 0/49 2/48
- Mammary Gland:
Carcinoma 0/50 0/50 0/50 2/50
|
| Non-Neoplastic Lesions | - Nasal Cavity: Olfactory epithelium, atrophy, degeneration, respiratory metaplasia
|
Female Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - Nasal Cavity: Olfactory epithelium, atrophy, respiratory metaplasia
|
Male Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
Adenoma 24/50 35/50 37/50 33/50 carcinoma 8/50 18/50 19/50 18/50 adenoma or carcinoma 28/50 43/50 43/50 43/50
|
| Non-Neoplastic Lesions | - Nasal Cavity: Olfactory epithelium, atrophy, respiratory metaplasia, degeneration; hyaline droplet accumulation; glands, hyperplasia
- Grandular stomach: Ulcer
- Forestomach: Hyperplasia, squamous; inflammation; ulcer
|
Female Mice: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| May Have Been Related | - All Organs:
Histiocytic sarcoma 0/49 1/50 1/50 4/50
|
| Non-Neoplastic Lesions | - Nasal cavity: Olfactory epithelium, atrophy, respiratory metaplasia, hyaline droplet accumulation; glands, hyperplasia
- Glandular stomach: Ulcer
- Forestomach: Hyperplasia, squamous; inflammation
|
