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Target Organs and Levels of Evidence for TR-552

Toxicology and Carcinogenesis Studies of Propargyl Alcohol (CASRN 107-19-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Propargyl alcohol
107-19-7		 05/17/2007 Inhalation
R: 0, 16, 32, OR 64 PPM M: 0, 8, 16, OR 32 PPM; 50/SEX/SPECIES		 Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: adenoma, respiratory epithelium (0/49, 0/49, 0/50, 3/49)
Non-Neoplastic Lesions
  • Nasal Cavity: hyperplasia, respiratory epithelium; hyperplasia, glands, respiratory epithelium; hyperplasia, basal cell, olfactory epithelium; hyperplasia, olfactory epithelium; hyperplasia, glands, olfactory epithelium; atrophy, olfactory epithelium; metaplasia, respiratory, olfactory epithelium; degeneration, olfactory epithelium; necrosis, olfactory epithelium; hyaline droplet accumulation, olfactory epithelium; inflammation, chronic active
Other Considerations
  • Mononuclear cell leukemia: 21/49, 26/50, 23/50, 37/50
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Nasal Cavity: hyperplasia, respiratory epithelium; hyperplasia, glands, respiratory epithelium; hyperplasia, basal cell, olfactory epithelium; hyperplasia, glands, olfactory epithelium; atrophy, olfactory epithelium; metaplasia, respiratory, olfactory epithelium; necrosis, olfactory epithelium; hyaline droplet accumulation, olfactory epithelium, inflammation, chronic active
Male Mice: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: adenoma, respiratory epithelium (0/49, 1/50, 4/50, 7/50)
May Have Been Related
  • Harderian Gland: adenoma 3/50, 10/50, 6/50, 11/50
Non-Neoplastic Lesions
  • Nasal Cavity: hyperplasia, respiratory epithelium; hyperplasia, glands, respiratory epithelium; metaplasia, squamous, respiratory epithelium; inflammation, suppurative; atrophy, turbinate; atrophy, olfactory epithelium; metaplasia, respiratory, olfactory epithelium
Female Mice: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: adenoma, respiratory epithelium (0/50, 2/50, 4/50, 6/50)
Non-Neoplastic Lesions
  • Nasal Cavity: hyperplasia, respiratory epithelium; hyperplasia, glands, respiratory epithelium; metaplasia, squamous, respiratory epithelium; inflammation, suppurative; atrophy, turbinate; atrophy, olfactory epithelium; metaplasia, respiratory, olfactory epithelium