Target Organs and Levels of Evidence for TR-552
Toxicology and Carcinogenesis Studies of Propargyl Alcohol (CASRN 107-19-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Propargyl alcohol 107-19-7 |
05/17/2007 |
Inhalation R: 0, 16, 32, OR 64 PPM M: 0, 8, 16, OR 32 PPM; 50/SEX/SPECIES |
Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Nasal Cavity: adenoma, respiratory epithelium (0/49, 0/49, 0/50, 3/49)
|
Non-Neoplastic Lesions |
- Nasal Cavity: hyperplasia, respiratory epithelium; hyperplasia, glands, respiratory epithelium; hyperplasia, basal cell, olfactory epithelium; hyperplasia, olfactory epithelium; hyperplasia, glands, olfactory epithelium; atrophy, olfactory epithelium; metaplasia, respiratory, olfactory epithelium; degeneration, olfactory epithelium; necrosis, olfactory epithelium; hyaline droplet accumulation, olfactory epithelium; inflammation, chronic active
|
Other Considerations |
- Mononuclear cell leukemia: 21/49, 26/50, 23/50, 37/50
|
Female Rats: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- Nasal Cavity: hyperplasia, respiratory epithelium; hyperplasia, glands, respiratory epithelium; hyperplasia, basal cell, olfactory epithelium; hyperplasia, glands, olfactory epithelium; atrophy, olfactory epithelium; metaplasia, respiratory, olfactory epithelium; necrosis, olfactory epithelium; hyaline droplet accumulation, olfactory epithelium, inflammation, chronic active
|
Male Mice: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Nasal Cavity: adenoma, respiratory epithelium (0/49, 1/50, 4/50, 7/50)
|
May Have Been Related |
- Harderian Gland: adenoma 3/50, 10/50, 6/50, 11/50
|
Non-Neoplastic Lesions |
- Nasal Cavity: hyperplasia, respiratory epithelium; hyperplasia, glands, respiratory epithelium; metaplasia, squamous, respiratory epithelium; inflammation, suppurative; atrophy, turbinate; atrophy, olfactory epithelium; metaplasia, respiratory, olfactory epithelium
|
Female Mice: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Nasal Cavity: adenoma, respiratory epithelium (0/50, 2/50, 4/50, 6/50)
|
Non-Neoplastic Lesions |
- Nasal Cavity: hyperplasia, respiratory epithelium; hyperplasia, glands, respiratory epithelium; metaplasia, squamous, respiratory epithelium; inflammation, suppurative; atrophy, turbinate; atrophy, olfactory epithelium; metaplasia, respiratory, olfactory epithelium
|