Target Organs and Levels of Evidence for TR-559
Toxicology and Carcinogenesis Studies of TEF evaluation (PCB 118) (CASRN 31508-00-6) in Harlan Sprague-Dawley Rats (Gavage Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
TEF evaluation (PCB 118)
31508-00-6 |
02/25/2009 |
Gavage
50 FEMALE RATS: 0, 100, 220, 460, 1000, 4600 UG/KG AND 4600 UG/KG (STOP EXPOSURE) |
Battelle Columbus Laboratory |
Levels of Evidence
Female Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: Cholangiocarcinoma 0/52 0/51 0/52 0/52 3/52 36/49 29/49 adenoma 0/52 1/51 1/52 4/52 12/52 24/49 1/49 hepatocholangioma 0/52 0/51 0/52 0/52 0/52 4/49 0/49
- Lung: Cystic keratinizing epithelioma 0/51 0/52 0/52 0/52 0/52 20/50 0/50
- Uterus: Carcinoma 2/52 2/52 1/52 3/52 4/52 3/52 11/50
|
| May Have Been Related |
- Pancreas Acinar Cell: Ademona 0/52 0/52 0/52 2/52 3/52 1/47 0/49 adenoma or carcinoma 0/50 0/52 0/52 2/52 3/52 2/47 0/49
- Uterus: Squamous cell carcinoma: 0/52 0/52 3/52 1/52 1/52 0/52 1/50
|
| Non-Neoplastic Lesions |
- Liver: Hepatocyte hypertrophy; multinucleated hepatocyte; eosinophilic focus; mixed cell focus; hyperplasia, nodular; inflammation; necrosis; fatty change, diffuse; bile duct hyperplasia; oval cell hyperplasia; bile duct cyst; pigmentation; cholangiofibrosis; toxic hepatopathy
- Lung: Alveolar epithelium, metaplasia, bronchiolar; squamous metaplasia
- Adrenal Cortex: Atrophy; cytoplasmic vacuolization
- Pancreas: Acinus, cytoplasmic vacuolization; artery, inflammation, chronic active
- Thyroid Gland: Follicular cell, hypertrophy
- Nasal Cavity: Inflammation; respiratory epithelium, hyperplasia
- Kidney: Pigmentation
|
