Toxic equivalency factor evaluation (PCB 118): Target Organs and Levels of Evidence for TR-559
Toxicology and Carcinogenesis Studies of TEF evaluation (PCB 118) (CASRN 31508-00-6) in Harlan Sprague-Dawley Rats (Gavage Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
TEF evaluation (PCB 118)
31508-00-6 | 02/25/2009 | Gavage
50 FEMALE RATS: 0, 100, 220, 460, 1000, 4600 UG/KG AND 4600 UG/KG (STOP EXPOSURE) | Battelle Columbus Laboratory |
Levels of Evidence
Female Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
Cholangiocarcinoma 0/52 0/51 0/52 0/52 3/52 36/49 29/49 adenoma 0/52 1/51 1/52 4/52 12/52 24/49 1/49 hepatocholangioma 0/52 0/51 0/52 0/52 0/52 4/49 0/49
- Lung:
Cystic keratinizing epithelioma 0/51 0/52 0/52 0/52 0/52 20/50 0/50
- Uterus:
Carcinoma 2/52 2/52 1/52 3/52 4/52 3/52 11/50
|
| May Have Been Related | - Pancreas Acinar Cell:
Ademona 0/52 0/52 0/52 2/52 3/52 1/47 0/49 adenoma or carcinoma 0/50 0/52 0/52 2/52 3/52 2/47 0/49
- Uterus:
Squamous cell carcinoma: 0/52 0/52 3/52 1/52 1/52 0/52 1/50
|
| Non-Neoplastic Lesions | - Liver: Hepatocyte hypertrophy; multinucleated hepatocyte; eosinophilic focus; mixed cell focus; hyperplasia, nodular; inflammation; necrosis; fatty change, diffuse; bile duct hyperplasia; oval cell hyperplasia; bile duct cyst; pigmentation; cholangiofibrosis; toxic hepatopathy
- Lung: Alveolar epithelium, metaplasia, bronchiolar; squamous metaplasia
- Adrenal Cortex: Atrophy; cytoplasmic vacuolization
- Pancreas: Acinus, cytoplasmic vacuolization; artery, inflammation, chronic active
- Thyroid Gland: Follicular cell, hypertrophy
- Nasal Cavity: Inflammation; respiratory epithelium, hyperplasia
- Kidney: Pigmentation
|
