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Target Organs and Levels of Evidence for TR-561

Toxicology and Carcinogenesis Studies of Tetralin (CASRN 119-64-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Tetralin 119-64-2	02/25/2009	Inhalation R&M: 0, 30, 60, OR 120 PPM; 50/SEX/SPECIES	Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Some Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Kidney: Cortical renal tubule adenoma (standard evaluation) 0/50 1/50 1/50 2/50 standard and extended combined 0/50 3/50 2/50 6/50
May Have Been Related	Testis: Ademona, interstitial cell 29/50 39/50 31/50 41/50
Non-Neoplastic Lesions	Kidney: Renal tubule, hyperplasia; severity of nephropathy; pelvis, transitional epithelium, hyperplasia Testis: Germinal epithelium, atrophy Nasal Cavity: Glands, dilatation; olfactory epithelium, degeneration; olfactory epithelium, basal cell hyperplasia; olfactory epithelium, metaplasia; olfactory epithelium, inflammation, suppurative; olfactory epithelium, mineralization; respiratory epithelium, inflammation, chronic

Female Rats: Some Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: Adenoma 0/50 0/50 0/50 3/50 adenoma or carcinoma 0/50 0/50 1/50 4/50 Uterus: Stromal polyp 6/50 10/50 9/50 17/50
Non-Neoplastic Lesions	Uterus: Endometrium hyperplasia Nasal Cavity: Glands, dilatation; olfactory epithelium, degeneration; olfactory epithelium, basal cell hyperplasia; olfactory epithelium, metaplasia; olfactory epithelium, inflammation, suppurative; olfactory epithelium, mineralization; respiratory epithelium, inflammation, chronic

Male Mice: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	Nasal Cavity: Glands, olfactory epithelium, hyperplasia; olfactory epithelium, atrophy; olfactory epithelium, metaplasia, respiratory; inflammation, suppurative Urinary Bladder: Transitional epithelium, eosinophilic granules, cytoplasmic

Female Mice: Equivocal Evidence

Type	Organ/Tissue (Lesion)
May Have Been Related	Spleen: Hemangiosarcoma 1/50 0/50 1/50 4/50
Non-Neoplastic Lesions	Nasal Cavity: Glands, olfactory epithelium, hyperplasia; olfactory epithelium, atrophy; olfactory epithelium, metaplasia, respiratory; inflammation, suppurative Urinary Bladder: Transitional epithelium, eosinophilic granules, cytoplasmic