Tetralin: Target Organs and Levels of Evidence for TR-561
Toxicology and Carcinogenesis Studies of Tetralin (CASRN 119-64-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Tetralin
119-64-2 | 02/25/2009 | Inhalation
R&M: 0, 30, 60, OR 120 PPM; 50/SEX/SPECIES | Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Kidney:
Cortical renal tubule adenoma (standard evaluation) 0/50 1/50 1/50 2/50 standard and extended combined 0/50 3/50 2/50 6/50
|
| May Have Been Related | - Testis:
Ademona, interstitial cell 29/50 39/50 31/50 41/50
|
| Non-Neoplastic Lesions | - Kidney: Renal tubule, hyperplasia; severity of nephropathy; pelvis, transitional epithelium, hyperplasia
- Testis: Germinal epithelium, atrophy
- Nasal Cavity: Glands, dilatation; olfactory epithelium, degeneration; olfactory epithelium, basal cell hyperplasia; olfactory epithelium, metaplasia; olfactory epithelium, inflammation, suppurative; olfactory epithelium, mineralization; respiratory epithelium, inflammation, chronic
|
Female Rats: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
Adenoma 0/50 0/50 0/50 3/50 adenoma or carcinoma 0/50 0/50 1/50 4/50
- Uterus:
Stromal polyp 6/50 10/50 9/50 17/50
|
| Non-Neoplastic Lesions | - Uterus: Endometrium hyperplasia
- Nasal Cavity: Glands, dilatation; olfactory epithelium, degeneration; olfactory epithelium, basal cell hyperplasia; olfactory epithelium, metaplasia; olfactory epithelium, inflammation, suppurative; olfactory epithelium, mineralization; respiratory epithelium, inflammation, chronic
|
Male Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - Nasal Cavity: Glands, olfactory epithelium, hyperplasia; olfactory epithelium, atrophy; olfactory epithelium, metaplasia, respiratory; inflammation, suppurative
- Urinary Bladder: Transitional epithelium, eosinophilic granules, cytoplasmic
|
Female Mice: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| May Have Been Related | - Spleen:
Hemangiosarcoma 1/50 0/50 1/50 4/50
|
| Non-Neoplastic Lesions | - Nasal Cavity: Glands, olfactory epithelium, hyperplasia; olfactory epithelium, atrophy; olfactory epithelium, metaplasia, respiratory; inflammation, suppurative
- Urinary Bladder: Transitional epithelium, eosinophilic granules, cytoplasmic
|
