Target Organs and Levels of Evidence for TR-561
Toxicology and Carcinogenesis Studies of Tetralin (CASRN 119-64-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Tetralin 119-64-2 |
02/25/2009 |
Inhalation R&M: 0, 30, 60, OR 120 PPM; 50/SEX/SPECIES |
Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Kidney: Cortical renal tubule adenoma (standard evaluation) 0/50 1/50 1/50 2/50 standard and extended combined 0/50 3/50 2/50 6/50
|
May Have Been Related |
- Testis: Ademona, interstitial cell 29/50 39/50 31/50 41/50
|
Non-Neoplastic Lesions |
- Kidney: Renal tubule, hyperplasia; severity of nephropathy; pelvis, transitional epithelium, hyperplasia
- Testis: Germinal epithelium, atrophy
- Nasal Cavity: Glands, dilatation; olfactory epithelium, degeneration; olfactory epithelium, basal cell hyperplasia; olfactory epithelium, metaplasia; olfactory epithelium, inflammation, suppurative; olfactory epithelium, mineralization; respiratory epithelium, inflammation, chronic
|
Female Rats: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: Adenoma 0/50 0/50 0/50 3/50 adenoma or carcinoma 0/50 0/50 1/50 4/50
- Uterus: Stromal polyp 6/50 10/50 9/50 17/50
|
Non-Neoplastic Lesions |
- Uterus: Endometrium hyperplasia
- Nasal Cavity: Glands, dilatation; olfactory epithelium, degeneration; olfactory epithelium, basal cell hyperplasia; olfactory epithelium, metaplasia; olfactory epithelium, inflammation, suppurative; olfactory epithelium, mineralization; respiratory epithelium, inflammation, chronic
|
Male Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- Nasal Cavity: Glands, olfactory epithelium, hyperplasia; olfactory epithelium, atrophy; olfactory epithelium, metaplasia, respiratory; inflammation, suppurative
- Urinary Bladder: Transitional epithelium, eosinophilic granules, cytoplasmic
|
Female Mice: Equivocal Evidence
Type |
Organ/Tissue (Lesion) |
May Have Been Related |
- Spleen: Hemangiosarcoma 1/50 0/50 1/50 4/50
|
Non-Neoplastic Lesions |
- Nasal Cavity: Glands, olfactory epithelium, hyperplasia; olfactory epithelium, atrophy; olfactory epithelium, metaplasia, respiratory; inflammation, suppurative
- Urinary Bladder: Transitional epithelium, eosinophilic granules, cytoplasmic
|