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https://ntp.niehs.nih.gov/go/35965

Target Organs and Levels of Evidence for TR-561

Toxicology and Carcinogenesis Studies of Tetralin (CASRN 119-64-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Tetralin
119-64-2		 02/25/2009 Inhalation
R&M: 0, 30, 60, OR 120 PPM; 50/SEX/SPECIES		 Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney: Cortical renal tubule adenoma (standard evaluation) 0/50 1/50 1/50 2/50 standard and extended combined 0/50 3/50 2/50 6/50
May Have Been Related
  • Testis: Ademona, interstitial cell 29/50 39/50 31/50 41/50
Non-Neoplastic Lesions
  • Kidney: Renal tubule, hyperplasia; severity of nephropathy; pelvis, transitional epithelium, hyperplasia
  • Testis: Germinal epithelium, atrophy
  • Nasal Cavity: Glands, dilatation; olfactory epithelium, degeneration; olfactory epithelium, basal cell hyperplasia; olfactory epithelium, metaplasia; olfactory epithelium, inflammation, suppurative; olfactory epithelium, mineralization; respiratory epithelium, inflammation, chronic
Female Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: Adenoma 0/50 0/50 0/50 3/50 adenoma or carcinoma 0/50 0/50 1/50 4/50
  • Uterus: Stromal polyp 6/50 10/50 9/50 17/50
Non-Neoplastic Lesions
  • Uterus: Endometrium hyperplasia
  • Nasal Cavity: Glands, dilatation; olfactory epithelium, degeneration; olfactory epithelium, basal cell hyperplasia; olfactory epithelium, metaplasia; olfactory epithelium, inflammation, suppurative; olfactory epithelium, mineralization; respiratory epithelium, inflammation, chronic
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Nasal Cavity: Glands, olfactory epithelium, hyperplasia; olfactory epithelium, atrophy; olfactory epithelium, metaplasia, respiratory; inflammation, suppurative
  • Urinary Bladder: Transitional epithelium, eosinophilic granules, cytoplasmic
Female Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Spleen: Hemangiosarcoma 1/50 0/50 1/50 4/50
Non-Neoplastic Lesions
  • Nasal Cavity: Glands, olfactory epithelium, hyperplasia; olfactory epithelium, atrophy; olfactory epithelium, metaplasia, respiratory; inflammation, suppurative
  • Urinary Bladder: Transitional epithelium, eosinophilic granules, cytoplasmic