Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/35965

Target Organs and Levels of Evidence for TR-561

Toxicology and Carcinogenesis Studies of Tetralin (CASRN 119-64-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Tetralin
119-64-2		 02/25/2009 Inhalation
R&M: 0, 30, 60, OR 120 PPM; 50/SEX/SPECIES		 Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney: Cortical renal tubule adenoma (standard evaluation) 0/50 1/50 1/50 2/50 standard and extended combined 0/50 3/50 2/50 6/50
May Have Been Related
  • Testis: Ademona, interstitial cell 29/50 39/50 31/50 41/50
Non-Neoplastic Lesions
  • Kidney: Renal tubule, hyperplasia; severity of nephropathy; pelvis, transitional epithelium, hyperplasia
  • Testis: Germinal epithelium, atrophy
  • Nasal Cavity: Glands, dilatation; olfactory epithelium, degeneration; olfactory epithelium, basal cell hyperplasia; olfactory epithelium, metaplasia; olfactory epithelium, inflammation, suppurative; olfactory epithelium, mineralization; respiratory epithelium, inflammation, chronic
Female Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: Adenoma 0/50 0/50 0/50 3/50 adenoma or carcinoma 0/50 0/50 1/50 4/50
  • Uterus: Stromal polyp 6/50 10/50 9/50 17/50
Non-Neoplastic Lesions
  • Uterus: Endometrium hyperplasia
  • Nasal Cavity: Glands, dilatation; olfactory epithelium, degeneration; olfactory epithelium, basal cell hyperplasia; olfactory epithelium, metaplasia; olfactory epithelium, inflammation, suppurative; olfactory epithelium, mineralization; respiratory epithelium, inflammation, chronic
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Nasal Cavity: Glands, olfactory epithelium, hyperplasia; olfactory epithelium, atrophy; olfactory epithelium, metaplasia, respiratory; inflammation, suppurative
  • Urinary Bladder: Transitional epithelium, eosinophilic granules, cytoplasmic
Female Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Spleen: Hemangiosarcoma 1/50 0/50 1/50 4/50
Non-Neoplastic Lesions
  • Nasal Cavity: Glands, olfactory epithelium, hyperplasia; olfactory epithelium, atrophy; olfactory epithelium, metaplasia, respiratory; inflammation, suppurative
  • Urinary Bladder: Transitional epithelium, eosinophilic granules, cytoplasmic