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https://ntp.niehs.nih.gov/go/35964

Goldenseal root powder: Target Organs and Levels of Evidence for TR-562

Toxicology and Carcinogenesis Studies of Goldenseal Root Powder (CASRN GOLDENSEALRT) in F344/N Rats and B6C3F1 Mice (Dosed-Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DateRoute/Exposure LevelsStudy Laboratory
Goldenseal root powder
GOLDENSEALRT
02/25/2009Dosed-Feed
R&M: 0, 3000, 9000, OR 25,000 PPM
Southern Research Institute

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: Adenoma: 1/50 1/50 2/50 10/50 adenoma or carcinoma 1/50 1/50 2/50 11/50
Non-Neoplastic Lesions
  • Liver: Hypertrophy; hepatocyte degeneration; eosinophilic focus
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: Adenoma: 0/50 0/50 1/50 8/50
Non-Neoplastic Lesions
  • Liver: Hypertrophy; hepatocyte degeneration; eosinophilic focus
Male Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: Hepatoblastoma 1/50 2/50 1/5 6/50 multiple adenoma 3/50 5/50 11/50 18/50
Non-Neoplastic Lesions
  • Liver: Eosinophilic focus
Female Mice: No Evidence