Target Organs and Levels of Evidence for TR-562
Toxicology and Carcinogenesis Studies of Goldenseal Root Powder (CASRN GOLDENSEALRT) in F344/N Rats and B6C3F1 Mice (Dosed-Feed Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Goldenseal root powder
GOLDENSEALRT |
02/25/2009 |
Dosed-Feed
R&M: 0, 3000, 9000, OR 25,000 PPM |
Southern Research Institute |
Levels of Evidence
Male Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: Adenoma: 1/50 1/50 2/50 10/50 adenoma or carcinoma 1/50 1/50 2/50 11/50
|
| Non-Neoplastic Lesions |
- Liver: Hypertrophy; hepatocyte degeneration; eosinophilic focus
|
Female Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: Adenoma: 0/50 0/50 1/50 8/50
|
| Non-Neoplastic Lesions |
- Liver: Hypertrophy; hepatocyte degeneration; eosinophilic focus
|
Male Mice: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: Hepatoblastoma 1/50 2/50 1/5 6/50 multiple adenoma 3/50 5/50 11/50 18/50
|
| Non-Neoplastic Lesions |
- Liver: Eosinophilic focus
|
Female Mice: No Evidence
