Target Organs and Levels of Evidence for TR-563
Toxicology and Carcinogenesis Studies of Pulegone (CAS No. 89-82-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Pulegone
89-82-7 |
11/19/2009 |
Gavage
MALE RATS: 0, 18.75, 37.5, OR 75 MG/KG; FEMALE RATS AND MALE & FEMALE MICE: 0, 37.5, 75, OR 150 MG/KG |
Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- Kidney: Hyaline glomerulopathy; severity of nephropathy; cyst
- Liver: Hepatocyte, cellular alteration, diffuse; fatty change; bile duct cyst; hepatocyte, necrosis; oval cell, hyperplasia; bile duct, hyperplasia; portal fibrosis
- Nasal Cavity: Olfactory epithelium, degeneration
- Forestomach: Inflammation; perforation; ulcer; epithelium, hyperplasia
|
Female Rats: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Urinary Bladder: Papilloma 0/50 0/49 1/50 3/47 papilloma or carcinoma 0/50 0/49 1/50 5/47
|
| Non-Neoplastic Lesions |
- Kidney: Hyaline glomerulopathy; nephropathy; severity of nephropathy
- Liver: Hepatocyte, cellular alteration, diffuse; fatty change; bile duct, cyst; hepatocyte, necrosis; oval cell, hyperplasia; bile duct, hyperplasia; portal fibrosis
- Nasal Cavity: Olfactory epithelium, degeneration, metaplasia; respiratory inflammation
|
Male Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: Hepatocellular: Adenoma 22/50 31/50 35/50 28/50 adenoma, carcinoma, or hepatoblastoma 29/50 37/50 42/50 36/50
|
| Non-Neoplastic Lesions |
- Kidney: Glomerulopathy, hyaline; glomerulus, congestion; severity of nephropathy
- Liver: Clear cell focus; eosinophilic focus; mixed cell focus; fatty change, focal; centrilobular, hepatocyte, hypertrophy; vein, intravascular hepatocyte; necrosis; bile duct, cyst; bile duct, hyperplasia; oval cell hyperplasia
- Nasal Cavity: Olfactory epithelium, degeneration; inflammation; nerve, atrophy; epithelium, metaplasia
- Forestomach: Hyperplasia, squamous; inflammation; ulcer
|
Female Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: Hepatocellular: Adenoma 13/49 15/50 13/50 27/50 adenoma, carcinoma or hepatoblastoma 17/49 15/50 15/50 33/50
|
| May Have Been Related |
- All Organs: Osteoma or osteosarcoma: 0/49 0/50 3/50 1/50
|
| Non-Neoplastic Lesions |
- Kidney: Glomerulopathy, hyaline; mineralization; nephropathy; glomerulus, congestion
- Liver: Clear cell focus; eosinophilic focus; mixed cell focus; fatty change, focal; centrilobular, hepatocyte, hypertrophy; vein, intravascular hepatocyte; necrosis; pigmentation; bile duct, cyst; bile duct, hyperplasia; oval cell hyperplasia
- Nasal Cavity: Olfactory epithelium, degeneration; inflammation; nerve, atrophy; epithelium, metaplasia
- Forestomach: Hyperplasia, squamous; inflammation
|
