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Target Organs and Levels of Evidence for TR-564

Toxicology and Carcinogenesis Studies of 1-Bromopropane (CAS No. 106-94-5) in F344/N Rats and B6C3F1 (Inhalation Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
1-Bromopropane
106-94-5		 11/19/2009 Inhalation
R: 0, 125, 250, OR 500 PPM; M: 0, 62.5, 125, OR 250 PPM; 50/SEX/SPECIES/DOSE		 Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Intestines: Large: Adenoma 0/50 0/50 2/50 1/50
  • Skin: Keratoacanthoma 0/50 3/50 6/50 6/50 keratoacanthoma or squamous cell carcinoma 1/50 4/50 6/50 8/50 keratoacanthoma, basal cell adenoma or carcinoma or squamous cell carcinoma 1/50 7/50 9/50 10/50
May Have Been Related
  • Mesothelium (Abdominal Cavity/Tunica Vaginalis): Malignant: 0/50 2/50 2/50 4/50
  • Pancreas Islet Cell: Adenoma 0/50 5/50 4/50 5/50
Non-Neoplastic Lesions
  • Nasal Cavity: Inflammation, suppurative, chronic; inflammation, chronic active; glands, hyperplasia
  • Larynx: Inflammation, chronic active
Female Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Intestines: Large: Adenoma 0/50 1/50 2/50 5/50
May Have Been Related
  • Skin: Squamous cell papilloma, keratoacanthoma, basal cell adenoma or carcinoma 1/50 1/50 1/50 4/50
Non-Neoplastic Lesions
  • Nasal Cavity: Inflammation, suppurative, chronic; inflammation, chronic active; glands, hyperplasia; respiratory epithelium, hyperplasia; olfactory epithelium metaplasia, respiratory
  • Larynx: Inflammation, chronic active; metaplasia, squamous
  • Trachea: Inflammation, chronic active; epithelium, hyperplasia
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Lung: Bronchiole, vacuolization cytoplasmic; bronchiole regeneration
  • Nasal Cavity: Respiratory epithelium, vacuolization cytoplasmic; respiratory epithelium, hyperplasia; olfactory epithelium, metaplasia, respiratory
  • Trachea: Vacuolization cytoplasmic
Female Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Lung: Alveolar/bronchiolar adenoma 1/50 6/50 4/50 10/50 alveolar/bronchiolar carcinoma 0/50 7/50 5/50 4/50 alveolar/bronchiolar adenoma or carcinoma 1/50 9/50 8/50 14/50
Non-Neoplastic Lesions
  • Lung: Bronchiole regeneration
  • Nasal Cavity: Respiratory epithelium, vacuolization cytoplasmic; respiratory epithelium, hyperplasia; olfactory epithelium, metaplasia, respiratory
  • Trachea: Vacuolization cytoplasmic
  • Larynx: Vacuolization cytoplasmic