Target Organs and Levels of Evidence for TR-564
Toxicology and Carcinogenesis Studies of 1-Bromopropane (CAS No. 106-94-5) in F344/N Rats and B6C3F1 (Inhalation Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
1-Bromopropane 106-94-5 |
11/19/2009 |
Inhalation R: 0, 125, 250, OR 500 PPM; M: 0, 62.5, 125, OR 250 PPM; 50/SEX/SPECIES/DOSE |
Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Intestines: Large: Adenoma 0/50 0/50 2/50 1/50
- Skin: Keratoacanthoma 0/50 3/50 6/50 6/50 keratoacanthoma or squamous cell carcinoma 1/50 4/50 6/50 8/50 keratoacanthoma, basal cell adenoma or carcinoma or squamous cell carcinoma 1/50 7/50 9/50 10/50
|
May Have Been Related |
- Mesothelium (Abdominal Cavity/Tunica Vaginalis): Malignant: 0/50 2/50 2/50 4/50
- Pancreas Islet Cell: Adenoma 0/50 5/50 4/50 5/50
|
Non-Neoplastic Lesions |
- Nasal Cavity: Inflammation, suppurative, chronic; inflammation, chronic active; glands, hyperplasia
- Larynx: Inflammation, chronic active
|
Female Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Intestines: Large: Adenoma 0/50 1/50 2/50 5/50
|
May Have Been Related |
- Skin: Squamous cell papilloma, keratoacanthoma, basal cell adenoma or carcinoma 1/50 1/50 1/50 4/50
|
Non-Neoplastic Lesions |
- Nasal Cavity: Inflammation, suppurative, chronic; inflammation, chronic active; glands, hyperplasia; respiratory epithelium, hyperplasia; olfactory epithelium metaplasia, respiratory
- Larynx: Inflammation, chronic active; metaplasia, squamous
- Trachea: Inflammation, chronic active; epithelium, hyperplasia
|
Male Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- Lung: Bronchiole, vacuolization cytoplasmic; bronchiole regeneration
- Nasal Cavity: Respiratory epithelium, vacuolization cytoplasmic; respiratory epithelium, hyperplasia; olfactory epithelium, metaplasia, respiratory
- Trachea: Vacuolization cytoplasmic
|
Female Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Lung: Alveolar/bronchiolar adenoma 1/50 6/50 4/50 10/50 alveolar/bronchiolar carcinoma 0/50 7/50 5/50 4/50 alveolar/bronchiolar adenoma or carcinoma 1/50 9/50 8/50 14/50
|
Non-Neoplastic Lesions |
- Lung: Bronchiole regeneration
- Nasal Cavity: Respiratory epithelium, vacuolization cytoplasmic; respiratory epithelium, hyperplasia; olfactory epithelium, metaplasia, respiratory
- Trachea: Vacuolization cytoplasmic
- Larynx: Vacuolization cytoplasmic
|