1-Bromopropane: Target Organs and Levels of Evidence for TR-564
Toxicology and Carcinogenesis Studies of 1-Bromopropane (CAS No. 106-94-5) in F344/N Rats and B6C3F1 (Inhalation Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
1-Bromopropane
106-94-5 | 11/19/2009 | Inhalation
R: 0, 125, 250, OR 500 PPM; M: 0, 62.5, 125, OR 250 PPM; 50/SEX/SPECIES/DOSE | Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Intestines:
Large: Adenoma 0/50 0/50 2/50 1/50
- Skin:
Keratoacanthoma 0/50 3/50 6/50 6/50 keratoacanthoma or squamous cell carcinoma 1/50 4/50 6/50 8/50 keratoacanthoma, basal cell adenoma or carcinoma or squamous cell carcinoma 1/50 7/50 9/50 10/50
|
| May Have Been Related | - Mesothelium (Abdominal Cavity/Tunica Vaginalis):
Malignant: 0/50 2/50 2/50 4/50
- Pancreas Islet Cell:
Adenoma 0/50 5/50 4/50 5/50
|
| Non-Neoplastic Lesions | - Nasal Cavity: Inflammation, suppurative, chronic; inflammation, chronic active; glands, hyperplasia
- Larynx: Inflammation, chronic active
|
Female Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Intestines:
Large: Adenoma 0/50 1/50 2/50 5/50
|
| May Have Been Related | - Skin:
Squamous cell papilloma, keratoacanthoma, basal cell adenoma or carcinoma 1/50 1/50 1/50 4/50
|
| Non-Neoplastic Lesions | - Nasal Cavity: Inflammation, suppurative, chronic; inflammation, chronic active; glands, hyperplasia; respiratory epithelium, hyperplasia; olfactory epithelium metaplasia, respiratory
- Larynx: Inflammation, chronic active; metaplasia, squamous
- Trachea: Inflammation, chronic active; epithelium, hyperplasia
|
Male Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - Lung: Bronchiole, vacuolization cytoplasmic; bronchiole regeneration
- Nasal Cavity: Respiratory epithelium, vacuolization cytoplasmic; respiratory epithelium, hyperplasia; olfactory epithelium, metaplasia, respiratory
- Trachea: Vacuolization cytoplasmic
|
Female Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Lung:
Alveolar/bronchiolar adenoma 1/50 6/50 4/50 10/50 alveolar/bronchiolar carcinoma 0/50 7/50 5/50 4/50 alveolar/bronchiolar adenoma or carcinoma 1/50 9/50 8/50 14/50
|
| Non-Neoplastic Lesions | - Lung: Bronchiole regeneration
- Nasal Cavity: Respiratory epithelium, vacuolization cytoplasmic; respiratory epithelium, hyperplasia; olfactory epithelium, metaplasia, respiratory
- Trachea: Vacuolization cytoplasmic
- Larynx: Vacuolization cytoplasmic
|
