https://ntp.niehs.nih.gov/go/LOE-TR-565

Target Organs and Levels of Evidence for TR-565

Toxicology and Carcinogenesis Studies of Milk Thistle Extract (CASRN 84604-20-6) in F344/N Rats and B6C3F1 Mice (Feed studies)

Chemical (Study Title)
CASRN
Peer Review Date Route/Exposure Levels Study Laboratory
Milk thistle extract
84604-20-6
11/19/2009 Dosed-Feed
R&M: 0, 12500, 25000, OR 50000 PPM; 50/SEX/SPECIES
Southern Research Institute

Levels of Evidence

Male Rats: No Evidence
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Liver: Clear cell focus, mixed cell focus
Decreased Incidences
  • Mammary Gland: Fibroadenoma
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Decreased Incidences
  • Liver: Hepatocellular adenoma and carcinoma
Female Mice: No Evidence